US 6,548,695 B2 · Process for producing isocoumarins and intermediates for the same

Abstract

Provided is a process for producing an isocoumarin-3-yl-acetic acid derivative, characterized by reacting a homophthalic acid derivative represented by a formula: (wherein Rc, R2 and R are mainly protecting groups) with a malonic acid derivating represented by a formula: (wherein R is an organic group including a lower alkyl group; R3 is a protecting group for a carboxyl group; and X is a halogen atom or a —OM group (wherein M is alkaline metal or alkaline earth metal)). According to the above process, various isocoumarin-3-yl-acetic acid derivatives can efficiently be provided.

Claims3

Dependent claims

A β-oxocarboxylic acid derivative represented by the following formula (II):

wherein R represents a hydrogen atom, a non-substituted or substituted alkyl group, a non-substituted or substituted alkenyl group, a non-substituted or substituted alkynyl group, a non-substituted or substituted alkoxyl group, a protected amino group, a hydroxyl group or a protected hydroxyl group;
Rc represents a non-substituted or substituted lower alkyl group;
R1 and R3 represent independently a protecting group for a carboxyl group;
and R2 represents a protecting group for a hydroxyl group.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

10/119,734Filed 11 Apr 2002 · division

Priority

JP 11-33447125 Nov 1999

Published

US 2002/0147350 A110 Oct 2002

Granted

15 Apr 2003

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

C07D 311/76
Ortho- or peri-condensed with carbocyclic rings or ring systems: benzo[c]pyrans
C07C 67/31
By modifying the acid moiety of the ester, such modification not being an introduction of an ester group: by introduction of functional groups…
C07C 67/343
By isomerisation; by change of size of the carbon skeleton: by increase in the number of carbon atoms
C07C 67/46
Preparation of carboxylic acid esters: from ketenes or polyketenes

Process for producing isocoumarins and intermediates for the same

Life of this patent

Process for producing isocoumarins and intermediates for the same

Life of this patent

Abstract

Claims3