Back to results
US 6,548,679 B1Granted
Antitumor agents
AssigneeThe Regents of the University of California
InventorsTrevor C. McMorris, Michael J. Kelner
Life of this patent
Estimating the term…
Abstract
The present invention provides compounds of general formula I or II: wherein R1, R2, R3, R4, R5, R6, and R7 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising compounds of formula I or II, intermediates and processes useful for preparing compounds of formula I or II, and methods comprising inhibiting tumor growth or treating cancer by administering one or more compounds of formula I or II.
Claims5
A compound of formula I:
- wherein
- R1 is —(CH2)n—(X)—(Y);
- n is 1;
- X is thio;
- Y is a 2 to 6 membered branched or unbranched carbon chain;
- wherein said chain is substituted on carbon with 1, 2, or 3, oxo, heteroaryl;
- and wherein said chain may optionally be saturated or unsaturated;
- R2 is hydrogen or (C1-C6)alkyl;
- R3 is hydrogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio, aryl, heteroaryl, aryloxy, or heteroaryloxy;
- R4 is hydrogen or (C1-C6)alkyl;
- and R5 is hydroxy, (C1-C6)alkoxy, or (C1-C6)alkanoyloxy;
- or R4 and R5 taken together are ethylenedioxy;
- R6 is hydrogen, carboxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, halo(C1-C6)alkyl, —C(═O)NRfRg, or (C1-C6)alkyl optionally substituted by 1 or 2 hydroxy, (C1-C6)alkoxy, (C1-C6)alkanoyloxy, carboxy, or —C(═O)NRfRg;
- Ra is hydrogen, (C1-C6)alkyl, (C1-C6)alkanoyl, phenyl or benzyl;
- and
- Rb, Rc, Rf and Rg are each independently hydrogen, (C1-C6)alkyl, (C1-C6)alkanoyl, phenyl or benzyl;
- or Rb and Rc or Rf and Rg, together with the nitrogen to which they are attached, are pyrrolidino, piperidino, or morpholino;
- wherein any aryl, heteroaryl, aryloxy, or heteroaryloxy of Y, or R3 may optionally be substituted by 1, 2, or 3 ((C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkanoyloxy, (C1-C6)alkoxycarbonyl, hydroxy (C1-C6)alkyl, halo(C1-C6)alkyl, hydroxy, halo, carboxy, mercapto, nitro, or —N(Rh)(Rj);
- wherein each Rh and Rj is independently hydrogen, (C1-C6)alkyl, (C1-C6)alkanoyl, phenyl or benzyl;
- or Rh and Rj together with the nitrogen to which they are attached are pyrrolidino, piperidino, or morpholino;
- or a pharmaceutically acceptable salt thereof.
18 more elements
The compound:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.