Methods for preparing 5- and 6-benzyl-functionalized quinoxalines
AssigneeAir Products and Chemicals, Inc.
InventorJuan Jesus Burdeniuc
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Abstract
The present invention pertains to methods for preparing 5- and 6-benzyl functionalized quinoxalines. In a first embodiment, the method comprises contacting an aqueous suspension of a 5- and 6-halomethyl quinoxaline with a water-soluble nucleophile. In a second embodiment, the method comprises contacting a 5- and 6-halomethyl quinoxaline with an organic solvent-soluble nucleophile in an inert polar organic solvent. In a third embodiment, the method comprises contacting a 5- and 6-halomethyl quinoxaline in an organic solvent with an aqueous solution of a water-soluble nucleophile in the presence of a phase transfer catalyst.
Claims10
A method for preparing a 5- or 6-benzyl functionalized compound having Formula (I)
- which comprises contacting a compound having Formula (II) in an organic solvent with an aqueous solution of a water-soluble nucleophile, N1, containing moiety Y, in the presence of a phase transfer catalyst;
- wherein X is chloro or bromo;
- R1 is selected from the group consisting of hydrogen and branched and unbranched alkyl and aryl groups having from 1 to 9 carbon atoms;
- and Y is hydroxy.
Dependencies are inferred from the claim text.