Sulfonamide derivative as a matrix metalloproteinase inhibitor

A compound represented as the following general formula(I), and its isomers and pharmaceutically acceptable salts thereof:

• wherein R1 denotes hydrogen, C1-12 alkyl, carbocyclic aryl-lower alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-lower alkyl, oxo C3-7 cycloalkyl, amino C3-7 cycloalkyl, thio C3-7 cycloalkyl, oxo C3-7 cycloalkyl-lower alkyl, amino C3-7 cycloalkyl-lower alkyl, thio C3-7 cycloalkyl-lower alkyl, C2-12 lower alkenyl, C2-12 lower alkynyl, carbocyclic aryl, heterocyclic aryl, heterocyclic aryl-lower alkyl, biaryl, halo lower alkyl, biaryl-lower alkylarylalkyl, hydroxy-lower alkyl, alkoxyloweralkyl, acyloxy-lower alkyl, alkyl thio lower alkyl, alkyl sulfinyl lower alkyl, alkyl sulfonyl lower alkyl, aryl thio lower alkyl, aryl sulfinyl lower alkyl, aryl sulfonyl lower alkyl, amino lower alkyl, mono lower alkyl amino lower alkyl, dialkylamino lower alkyl, acylamino lower alkyl, N-lower alkyl-piperazino-lower alkyl, N-(carbocyclic aryl-lower alkyl) piperazino-lower alkyl, heterocyclic aryl-lower alkyl piperazino-lower alkyl, morpholino-lower alkyl, thiomorpholino-lower alkyl, piperidino-lower alkyl, pyrrolidino-lower alkyl or piperidyl-lower alkyl;
• R2 denotes hydrogen, lower alkyl, carbocyclic aryl-lower alkyl, C1-4 carbocyclic aryl-lower alkyl, C1-4 heterocyclic aryl-lower alkyl, C1-5 alkoxyphenyl-lower alkyl, C1-5 alkenoxyphenyl-lower alkyl, C1-5 alkynoxyphenyl-lower alkyl, heterocyclic aryl-lower alkyl, hydroxy-lower alkyl, alkoxyloweralkyl, acyloxy-lower alkyl, thio-lower alkyl, alkyl-thio lower alkyl, alkyl-sulfinyl lower alkyl, alkyl-sulfonyl lower alkyl, aryl-thio lower alkyl, aryl-sulfinyl lower alkyl, aryl-sulfonyl lower alkyl, amino lower alkyl, mono lower alkyl amino lower alkyl, dialkylamino lower alkyl, carboxyl-lower alkyl or acylamino lower alkyl;
• R3 denotes hydrogen or C1-6 lower alkyl;
• R4 denotes hydrogen, C1-12 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-lower alkyl, oxo C3-7 cycloalkyl, amino C3-7 cycloalkyl, thio C3-3 cycloalkyl, oxo C3-4 cycloalkyl-lower alkyl, amino C3-7 cycloalkyl-lower alkyl, thio C3-7 cycloalkyl-lower alkyl, carbocyclic aryl, carbocyclic aryl-lower alkyl, heterocyclic aryl, heterocyclic aryl-lower alkyl, biaryl, biaryl-lower alkyl, halo lower alkyl, hydroxy-lower alkyl, alkoxyloweralkyl, acyloxy-lower alkyl, alkyl-thio lower alkyl, alkyl-sulfinyl lower alkyl, alkyl-sulfonyl lower alkyl, aryl-thio lower alkyl, aryl-sulfinyl lower alkyl, aryl-sulfonyl lower alkyl, amino lower alkyl, mono lower alkyl amino lower alkyl, dialkylamino lower alkyl, acylamino lower alkyl, carboxyl lower alkyl, N-lower alkyl-piperazino-lower alkyl, N-carbocyclic aryl piperazino-lower alkyl, heterocyclic aryl piperazino-lower alkyl, morpholino-lower alkyl, thiomorpholino-lower alkyl, piperidino-lower alkyl, pyrrolidino-lower alkyl, or piperidyl-lower alkyl;
• R5 denotes hydroxyl, alkoxyl, halogen, thiol, thioalkoxyl or hydroxylamine;
• and, or
• X1 and X2 denote S, O of N—R7, wherein R7 is hydrogen, C1-6-lower alkyl, aryl, heteroaryl or arylalkyl
• wherein R2 can form a ring together with either R3 or R4.