Tricyclic compounds and their use in medicine process for their preparation and pharmaceutical compositions containing them
AssigneesDr. Reddy's Research Foundation, Reddy-Cheminor, Inc.
InventorsBraj Bhushan Lohray, Vidya Bhushan Lohray, Ashok Channaveerappa Bajji, Shivaramayya Kalchar, Rao Bheema Paraselli, Ranga Madhavan Gurram
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Abstract
A compound of Formula (Ig) The compounds may be used, inter alia, for preparing beta aryl-alpha-oxy substituted alkylcarboxylic acids.
Claims8
A compound of formula (Ig)
- where R1, R2, R3, R4 are the same or different and represent hydrogen, halogen, hydroxy, nitro, cyano, formyl or unsubstituted or substituted groups selected from alkyl, cycloalkyl, alkoxy, cycloalkoxy, aryl, aryloxy, aralkyl, aralkoxy, heterocyclyl, heteroaryl, heteroaralkyl, heteroaryloxy, heteroaralkoxy, acyl, acyloxy, hydroxyalkyl, amino, acylamino, monoalkylamino, dialkylamino, arylamino, aralkylamino, aminoalkyl, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, alkoxyalkyl, aryloxyalkyl, aralkoxyalkyl, alkylthio, thioalkyl, alkoxycarbonylamino, aryloxycarbonylamino, aralkoxycarbonylamino, carboxylic acid or its derivatives, or sulfonic acid or its derivatives;
- the ring A fused to the ring containing X and N represents a 6 or 6 membered cyclic structure containing carbon atoms, which optionally contains one or more heteroatoms selected from oxygen, sulfur or nitrogen atoms, which optionally may be substituted;
- the ring A is saturated or contains one or more double bonds or is an aromatic moiety;
- X represents a heteroatom selected from oxygen, sulfur or NR9 where R9 is hydrogen, alkyl, aryl, aralkyl, acyl, alkoxycarbonyl, aryloxycarbonyl or aralkoxycarbonyl groups;
- Ar represents an unsubstituted or substituted divalent single or fused aromatic or heterocyclic group;
- R5 represents hydrogen atom, hydroxy, alkoxy, halogen, lower alkyl or unsubstituted or substituted aralkyl group or forms a bond together with the adjacent group R6, R6 represents hydrogen, hydroxy, alkoxy, halogen, lower alkyl group, acyl or unsubstituted or substituted aralkyl or R6 forms a bond together with R5;
- R7 represents hydrogen or unsubstituted or substituted groups selected from alkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl, alkoxycarbonyl, aryloxycarbonyl, alkylaminocarbonyl, arylaminocarbonyl, acyl, heterocyclyl, heteroaryl or heteroaralkyl groups;
- n is an integer ranging from 1-4 and m is an integer 0 or 1 or steroisomers thereof.
A compound according to 1 wherein the cyclic structure A represents phenyl or pyridyl ring.
A compound according to 1 wherein Ar represents unsubstituted or substituted divalent phenylene, naphtylene, pyridyl, quinolinyl, benzofuryl, benzopyranyl, benzoxayolyl, benzothiazolyl, indolyl, indolinyl, azaindolyl, azaindolinyl, indenyl, dihydrobenzofuryl, dihydrobenzopyranyl or pyrazolyl group.
A compound according to 1 wherein when m=0, Ar represents a divalent benzofuranyl, benzoxazolyl, benzothiazolyl, indolyl, indolinyl, dihydrobenzofuryl or dihydrobenzopyranyl group.
A compound according to 1 wherein when m=1, Ar presents divalent phenylene, naphthylene, pyridyl, quinolinyl, benzofuranyl, benzoxazolyl, benzothiazolyl, indolyl, indolinyl, azaindolyl, azaindolinyl, indenyl, dihydrobenzofuryl. benzopyranyl, dihydrobenzopyranyl or pyrazolyl groups.
Dependencies are inferred from the claim text.