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US 6,548,665 B2Granted
Asymmetric synthesis of a key intermediate for making benazepril and analogues thereof
AssigneeScinoPharm Taiwan, Ltd.
InventorsWei-Hong Tseng, George Schloemer
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Abstract
The present invention provides a method of converting an intermediate compound to the desired S,S diastereomer for efficiently making benazepril and analogues thereof.
Claims7
A process of epimerizing a carboxylic acid compound of formula II
- wherein R1 is hydrogen, or a lower alkyl group having 1 to 4 carbon atoms, to increase the amount of the SS diastereomer of the compound of formula II by refluxing the carboxylic acid compound of formula II in a solution comprising an organic solvent.
Dependencies are inferred from the claim text.