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US 6,548,651 B1Granted
Modified peptide nucleic acid (PNA) molecules
AssigneesPantheco A/S, Peter E. Nielsen
InventorsPeter E. Nielsen, Liam Good, Henrik Frydenlund Hansen, Frederik Beck, Leila Malik, Carsten Schou, Margit Wissenbach, Birgit Kjaeldgaard Giwercman
Life of this patent
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Abstract
The present invention relates to novel drugs which may be used in combating infectious micro-organisms, particularly bacteria. More specifically, the invention relates to peptide nucleic acid (PNA) sequences that are modified by conjugating cationic peptides to the PNA moiety in order to obtain novel PNA molecules that exhibit enhanced anti-infective properties.
Claims1
A modified PNA molecule comprising:
- H-KFFKFFKFFK-ado-TTC AAA CAT AGT-NH2, H-FFKFFKFFK-GGC-smcc-ado-TTC AAA CAT AGT-NH2, H-FFRFFRFFR-GGC-smcc-ado-TTC AAA CAT AGT-NH2, H-LLKLLKLLK-GGC-smcc-ado-TTC AAA CAT AGT-NH2, H-LLRLLRLLR-GGC-smcc-ado-TTC AAA CAT AGT-NH2, H-LLKKLAKALK-GC-smcc-ado-TTC AAA CAT AGT-NH2, H-KRRWPWWPWKK-C-smcc-ado-TTC AAA CAT AGT-NH2, H-KFKVKFVVKK-GC-smcc-ado-TTC AAA CAT AGT-NH2, H-LLKLLLKLLLK-C-smcc-ado-TTC AAA CAT AGT-NH2, H-FFKFFKFFK-GGC-smcc-ado-TTC AAA CAT AGT-NH2, H-KFFKFFKFFK-C-smcc-ado-TTC AAA CAT AGT-NH2, H-ado-TTC AAA CAT AGT-NH2, H2N-KFFKVKFVVKK-C-smcc-ado-TTC AAA CAT AGT-NH2, H2N-KKFKVKFVVKKC-achc-β.ala-TTCAAACATAGT-NH2, H-KFFKFFKFFK-achc-β.ala-TCAAACATAGT-NH2, H2N-KKFKVKFVVKKC-lcsmcc-ado-TTCAAACATAGT-NH2, H2N-KKFKVKFVVKKC-mbs-ado-TTCAAACATAGT-NH2, H2N-KKFKVKFVVKKC-emcs-ado-TTCAAACATAGT-NH2, H2N-KKFKVKFVVKKC-smph-ado-TTCAAACATAGT-NH2, H2N-KKFKVKFVVKKC-amas-ado-TTCAAACATAGT-NH2, H2N-KKFKVKFVVKKC-smpb-ado-TTCAAACATAGT-NH2, H2N-KKFKVKFVVKKC-lcsmcc-gly-TTCAAACATAGT-NH2, H2N-KKFKVKFVVKKC-lcsmcc-β.ala-TTCAAACATAGT-NH2, H2N-KKFKVKFVVKKC-lcsmcc-β.cypr-TTCAAACATAGT-NH2, H2N-KKFKVKFVVKKC-lcsmcc-aha-TTCAAACATAGT-NH2, H2N-KKFKVKFVVKKC-lcsmcc-ado-TTCAAACATAGT-NH2, H-KFFKFFKFFK-ado-ado-TTCAAACATAGT-NH2, H-KFFKFFKFFK-ado-Gly-TTCAAACATAGT-NH2, H-KFFKFFKFFK-ado-P-TTCAAACATAGT-NH2, H-KFFKFFKFFK-ado-aha-TTCAAACATAGT-NH2, H-KFFKFFKFFK-ado-β.ala-TTCAAACATAGT-NH2, H-KFFKFFKFFK-ado-achc-TTCAAACATAGT-NH2, H-KFFKFFKFFK-Gly-ado-TTCAAACATAGT-NH2, H-KFFKFFKFFK-Gly-Gly-TTCAAACATAGT-NH2, H-KFFKFFKFFK-Gly-P-TTCAAACATAGT-NH2, H-KFFKFFKFFK-Gly-aha-TTCAAACATAGT-NH2, H-KFFKFFKFFK-Gly-β.ala-TTCAAACATAGT-NH2, H-KFFKFFKFFK-Gly-achc-TTCAAACATAGT-NH2, H-KFFKFFKFFK-P-ado-TTCAAACATAGT-NH2, H-KFFKFFKFFK-P-Gly-TTCAAACATAGT-NH2, H-KFFKFFKFFK-P-P-TTCAAACATAGT-NH2, H-KFFKFFKFFK-P-aha-TTCAAACATAGT-NH2, H-KFFKFFKFFK-P-β.ala-TTCAAACATAGT-NH2, H-KFFKFFKFFK-P-achc-TTCAAACATAGT-NH2, H-KFFKFFKFFK-aha-ado-TTCAAACATAGT-NH2, H-KFFKFFKFFK-aha-Gly-TTCAAACATAGT-NH2, H-KFFKFFKFFK-aha-P-TTCAAACATAGT-NH2, H-KFFKFFKFFK-aha-aha-TTCAAACATAGT-NH2, H-KFFKFFKFFK-aha-β.ala-TTCAAACATAGT-NH2, H-KFFKFFKFFK-aha-achc-TTCAAACATAGT-NH2, H-KFFKFFKFFK-β.ala-ado-TTCAAACATAGT-NH2, H-KFFKFFKFFK-β.ala-Gly-TTCAAACATAGT-NH2, H-KFFKFFKFFK-β.ala-P-TTCAAACATAGT-NH2, H-KFFKFFKFFK-β.ala-aha-TTCAAACATAGT-NH2, H-KFFKFFKFFK-β.ala-β.ala-TTCAAACATAGT-NH2, H-KFFKFFKFFK-β.ala-achc-TTCAAACATAGT-NH2, H-KFFKFFKFFK-P-p-TTCAAACATAGT-NH2, H-KFFKFFKFFK-P-P-TTCAAACATAGT-NH2, H-KFFKFFKFFK-K-K-TTCAAACATAGT-NH2, H-KFFKFFKFFK-F-F-TTCAAACATAGT-NH2, H-KFFKFFKFFK-F-K-TTCAAACATAGT-NH2, H-KFFKFFKFFK-K-F-TTCAAACATAGT-NH2, H-KFFKFFKFFK-phg-ado-TTCAAACATAGT-NH2, H-KFFKFFKFFK-phg-Gly-TTCAAACATAGT-NH2, H-KFFKFFKFFK-phg-P-TTCAAACATAGT-NH2, H-KFFKFFKFFK-phg-aha-TTCAAACATAGT-NH2, H-KFFKFFKFFK-phg-β.ala-TTCAAACATAGT-NH2, H-KFFKFFKFFK-phg-achc-TTCAAACATAGT-NH2, H-KFFKFFKFFK-achc-ado-TTCAAACATAGT-NH2, H-KFFKFFKFFK-achc-Gly-TTCAAACATAGT-NH2, H-KFFKFFKFFK-achc-P-TTCAAACATAGT-NH2, H-KFFKFFKFFK-achc-aha-TTCAAACATAGT-NH2, H-KFFKFFKFFK-achc-β.ala-TTCAAACATAGT-NH2 or H-KFFKFFKFFK-achc-achc-TTCAAACATAGT-NH2.
Dependencies are inferred from the claim text.