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US 6,548,645 B1Granted
Immunoassay for 2-oxo-3-hydroxy LSD
AssigneeMicrogenetics Corporation
InventorsAnthony de Jesus Sanchez, David Davoudzadeh, William A. Coty
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Abstract
To improve the detection of LSD, and LSD metabolites in biological samples, antibodies are raised to 2-oxo-3-hydroxy-LSD conjugated to a protein carrier. Selected antibodies are matched with an immunoassay reagent in which the 2-oxo-3-hydroxy-LSD is conjugated in the same position to a labeling or separation means. The set of reagents can be used in immunoassays for detecting or confirming the presence of LSD or LSD metabolites in a sample potentially containing interfering substances.
Claims9
A compound of the formula
- wherein X is —L1—Z, where L1 is a linker containing at least one carbon atom;
- wherein Z is selected from the group consisting of
- —NH2,
- —COOH,
- —SH,
- —NH—C(═O)—L2—M,
- and a moiety which reacts with a protein to form a covalent bond;
- where L2 is a linker containing at least one carbon atom;
- where M is halide or maleimide;
- and
- wherein J is —O—, —S—, —NH— or —CH2—.
8 more elements
Dependencies are inferred from the claim text.