Antigen carbohydrate compounds and their use in immunotherapy
AssigneeThe Austin Research Institute
InventorsIan F. C. McKenzie, Vasso Apostolopoulos, Geoff Allan Pietersz
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Abstract
Conjugates between whole antigen or one or more repeated subunits of an antigen and a carbohydrate polymer are described. Also described are immunogenic vaccines against disease states which contain the conjugates and methods for inducing cell-mediated immune responses. The conjugates may especially contain polymers of the carbohydrate mannose and one or more repeated subunits of human mucin or non-repeated regions of human mucin.
Claims22
An immunogenic peptide, protein or portion thereof which is effective to elicit an immune response comprising an amino acid sequence of non-VNTR, non leader regions of mucin.
A compound comprising a conjugate between an immunogenic peptide, protein or portion thereof which is effective to elicit an immune response comprising an amino acid sequence of non VNTR, non leader regions of mucin and carbohydrate polymer.
A immunogenic vaccine against disease states which comprises an immunogenic peptide, protein or portion thereof which is effective to elicit an immune response comprising an amino acid sequence of non VNTR, non leader regions of mucin optionally with an adjuvant in association with a pharmaceutically acceptable carrier.
A compound comprising a conjugate between native MUC1 and a carbohydrate polymer.
Dependencies are inferred from the claim text.