PTP 1D: a novel protein tyrosine phosphatase
AssigneeMax-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.
InventorsAxel Ullrich, Wolfgang Vogel
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Abstract
A novel protein tyrosine phosphatase is the protein designated PTP 1D. The PTP 1D protein may be produced by recombinant means, for example using a nucleic acid construct encoding the protein as provided herein. Also disclosed is an antibody specific for an epitope of PTP 1D, protein. Methods for identifying compounds which bind to a PTP 1D protein and inhibit or stimulate its enzymatic activity, pharmaceutical compositions comprising PTP 1D, and methods for treating a disease associated with PTP 1D, and methods for treating a disease associated with PTP 1D protein using such compositions, are provided.
Claims10
An isolated antibody which binds to a polypeptide consisting of the amino acid sequence of SEQ ID NO:5, amino acid residues 6-101 of SEQ ID NO:5, amino acid residues 112-215 of SEQ ID NO:5, amino acid residues 216-275 of SEQ ID NO:5, amino acid residues 276-517 of SEQ ID NO:5 or amino acid residues 518-593 of SEQ ID NO:5.
An isolated antibody which binds to the polypeptide of SEQ ID NO:5.
An isolated antibody which binds to a polypeptide encoded by nucleotides 226 to 780 of SEQ ID NO:4.
Dependencies are inferred from the claim text.