Synthetic peptides having FGF receptor affinity
AssigneeChiron Corporation
InventorsMarcus Ballinger, Michael Kavanaugh
Life of this patent
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Abstract
Peptidic compositions having FGF receptor affinity, as well as fusion proteins and oligomers of the same, are provided. The subject peptidic compounds are characterized by having little or no homology to naturally occurring bFGF. The subject fusion proteins include the peptidic composition linked to an oligomerization domain, either directly or through a linking group and optionally further include a heparin binding domain. The subject peptidic compositions, fusion proteins and oligomers thereof find use in a variety of applications, including both research and therapeutic applications, in which FGF receptor ligands are employed.
Claims12
A peptidic compound that binds to a fibroblast growth factor (FGF) receptor, wherein said peptidic compound comprises the sequence Ψ-F-X-Φ-Ω, wherein Ψ is L or M, X is any amino acid, Φ is V, L, Y, or C, and Ω is V, W, L, Y, or C, and wherein said peptidic compound has a length of from 10 to 40 monomeric units.
Dependencies are inferred from the claim text.