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AssigneeBiomerieux
InventorsAnthony L. DeVico, Ranajit Pal, Robert C. Gallo, Phillip D. Markham, Alfredo Garzino-Demo
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The present invention relates to therapeutic compositions of macrophage derived chemokine (MDC) and methods for treating and preventing infection by a lentivirus, particularly an immunodeficiency virus, particularly HIV, using MDC proteins, nucleic acids and/or derivatives or analogues thereof. The present invention further relates to methods for detection and prognosis of lenivirus infection, particularly HIV infection using MDC as a prognostic indicator. The present invention further provides MDC proteins, nucleic acids encoding such proteins, that have amino-terminal sequences that differ from other MDC isolates. Recombinant host cells and methods of production are also provided.
A purified protein consisting of amino acids 2-69 of SEQ ID NO:2.
A purified protein consisting of amino acids 3-69 of SEQ ID NO:2.
A purified protein consisting of the amino acid sequence Tyr-Gly-Ala-Asn-Met-Glu-Asp-Ser-Val-Cys-Cys-Arg-Asp-Tyr-Val-Arg-Tyr-Arg-Leu (amino acids 3-21 of SEQ ID NO:2).
A purified protein consisting of the amino acid sequence Pro-Tyr-Gly-Ala-Asn-Met-Glu-Asp-Ser-Val-Cys-Cys-Arg (amino acids 2-14 of SEQ ID NO:2).
Dependencies are inferred from the claim text.