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US 6,548,553 B2Granted
Styryl sulfone anticancer agents
AssigneeTemple University of the Commonwealth System of Higher Education
InventorsE. Premkumar Reddy, M. V. Ramana Reddy
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AssigneeTemple University of the Commonwealth System of Higher Education
InventorsE. Premkumar Reddy, M. V. Ramana Reddy
Estimating the term…
Styryl sulfone compounds of the invention selectively inhibit proliferation of tumor cells, and induce apoptosis of tumor cells, while sparing normal cells. The compounds, which are useful in the treatment of cancer and other proliferative disorders, have (a) the formula II: wherein n is zero or one; R1 is selected from the group consisting of hydrogen, chlorine, fluorine and bromine; R2 is selected from the group consisting of hydrogen, chlorine, fluorine, bromine, methyl and methoxy; and R3 is selected from the group consisting of hydrogen, chlorine and fluorine; provided, R2 may not be methyl or methoxy when R1 and R3 are both hydrogen and n is zero or one; and R1, R2 and R3 may not all be hydrogen when n is one; (b) the formula III: wherein R1 is selected from the group consisting of hydrogen, chlorine, fluorine and bromine; or (c) or the formula IV: wherein R1 is selected from the group consisting of fluorine and bromine, and R2 is selected from the group consisting of 2-chlorophenyl, 4-chlorophenyl, 4-fluorophenyl and 2-nitrophenyl.
A method of treating an individual for a cancer other than prostate or breast cancer comprising administering to said individual an effective amount of a compound of formula II
A method of inhibiting the growth of tumor cells in an individual afflicted with cancer, other than breast or prostate tumor cells, comprising administering to said individual an effective amount of a compound of formula II
A method of treating an individual for a cancer other than prostate or breast cancer comprising administering to said individual an effective amount of a compound of formula III
A method of inhibiting the growth of tumor cells in an individual afflicted with cancer, other than breast or prostate tumor cells, comprising administering to said individual an effective amount of a compound of formula III
A method of treating an individual for a cancer other than prostate or breast cancer comprising administering to said individual an effective amount of a compound of formula IV
A method of inhibiting the growth of tumor cells in an individual afflicted with cancer, other than breast or prostate tumor cells, comprising administering to said individual an effective amount of a compound of formula IV
Dependencies are inferred from the claim text.