Sulfonylamino carboxylic acid N-arylamides as guanylate cyclase activators

A compound of the formula Ik

• in any stereoisomeric form,
• or a physiologically tolerable salt thereof,
• or a mixture thereof,
• in which
• the ring A2, which includes the carbon atoms which carry the groups CO—NH—A1 and NH—SO2R2, is a benzene ring;
• R1 is a substituent from the group consisting of CO—(C1-C10)-alkyl, CO-aryl, CO—NR5R6, —NH—CO—(C1-C10)-alkyl, —NH—CO-aryl, —N(CO—(C1-C10)-alkyl)2, —N(CO-aryl)2, —NH—SO2-(C1-C10)-alkyl, —NH—SO2-aryl, —N(SO2—(C1-C10)-alkyl)2 and —N(SO2-aryl)2, in which all alkyl radicals can be substituted by one or more identical or different radicals R4;
• R2 is aryl or NR5R6;
• R3is one or more identical or different substituents from the group consisting of hydrogen, halogen, CF3, OH, —O—(C1-C10)-alkyl, —O—(C1-C7)-alkyl-R7, —O-aryl, SH, —S—(C1-C10)-alkyl, —S—(C1-C7)-alkyl-R7, —S-aryl, (C1-C2)-alkylenedioxy, CN, NO2, NR8R9, CO—NR5R6, COOH, CO—O—(C1-C5)-alkyl, S(O)n—(C1-C7)-alkyl, S(O)n-aryl, S(O)n—NR5R6 and (C1-C7)-alkyl that can be substituted by one or more identical or different radicals R4;
• R4 is fluorine, OH, —O—(C1-C10)-alkyl, —O—(C1-C7)-alkyl-R7, —O-aryl, SH, —S—(C1-C10)-alkyl, —S—(C1-C7)-alkyl-R7, —S-aryl, CN, NR8R9, CO—NH2, CO—NH—(C1-C3)-alkyl, CO—N((C1-C3)-alkyl)2, COOH, CO—O—(C1-C5)-alkyl or oxo;
• R5 is hydrogen, (C1-C10)-alkyl that can be substituted by one or more identical or different substituents R4 and/or by aryl, or is aryl, CO—(C1-C10)-alkyl, CO-aryl, SO2—(C1-C10)-alkyl or SO2-aryl;
• R6, independently of R5, has one of the meanings indicated for R5;
• R7 is OH, —O—(C1-C7)-alkyl, NH2, —NH—(C1-C4)-alkyl or —N((C1-C4)-alkyl)2;
• R8 is hydrogen or (C1-C7)-alkyl that can be substituted by one or more identical or different substituents from the group consisting of OH, —O—(C1-C5)-alkyl, NH2, —NH—(C1-C4)-alkyl and —N((C1-C4)-alkyl)2;
• R9, independently of R8, has one of the meanings of R8 or is CO—(C1-C4)-alkyl;
• aryl is phenyl or naphthyl, which can both be substituted by one or more identical or different substituents from the group consisting of halogen, (C1-C5)-alkyl, phenyl, tolyl, CF3, NO2, OH, —O—(C1-C5)-alkyl, —O—(C2-C4)-alkyl-O—(C1-C3)-alkyl, (C1-C2)-alkylenedioxy, NH2, —NH—(C1-C3)-alkyl, —N((C1-C3)-alkyl)2, NH—CHO, —NH—CO—(C1-C5)-alkyl, CN, CO—NH2, CO—NH—(C1-C3)-alkyl, CO—N((C1-C3)-alkyl)2, COOH, CO—O—(C1-C5)-alkyl, CHO, CO—(C1-C5)-alkyl, S(O)n—(C1-C4)-alkyl, S(O)n—phenyl, S(O)n—tolyl, S(O)2—NH2, S(O)2—NH—(C1-C3)-alkyl and S(O)2—N((C1-C3)-alkyl)2;
• n is 0, 1 or 2;
• and
• m is 2, 3 or 4.