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US 6,548,546 B2Granted
HIV integrase inhibitors
AssigneeBristol-Myers Squibb Company
InventorsMichael A. Walker, Timothy D. Johnson, Oak K. Kim, Yunhui Zhang
Life of this patent
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Abstract
The present invention relates to HIV integrase inhibitors of the formula wherein R1 and Z are as defined in the specification.
Claims13
A compound of the formula
- or a tautomer thereof, wherein:
- (a) R1 is phenyl, wherein said phenyl is substituted from 1-3 times with R2, or R1 is naphthyl, wherein said naphthyl is optionally substituted from 1-3 times with R2;
- (b) each R2 is independently selected from halo, C1-C3 alkyl, C1-C2 alkoxy, C1-C3 haloalkyl, and phenyl-(CH2)mOn—;
- (c) m is 0 or 1;
- (d) n is 0 or 1;
- and
- (e) Z is methylene or —C(O)—, provided that when Z is methylene said substituted phenyl is not para-methoxy phenyl or when Z is —C(O)— said substituted phenyl is not ortho-chloro phenyl,
- or a pharmaceutically acceptable salt, solvate or prodrug of said compound or tautomer thereof.
5 more elements
A pharmaceutical composition, comprising
- a) a compound of the formula
- or a tautomer thereof, wherein:
- R1a is phenyl, wherein said phenyl is substituted from 1-3 times with R2, or R1a is naphthyl, wherein said naphthyl is optionally substituted from 1-3 times with R2;
- each R2 is independently selected from halo, C1-C3 alkyl, C1-C2 alkoxy, C1-C3 haloalkyl, and phenyl-(CH2)mOn—;
- m is 0 or 1;
- n is 0 or 1;
- and
- Z is methylene or —C(O)—, provided that when
- Z is —C(O)— said substituted phenyl is not ortho-chloro phenyl,
- or a pharmaceutically acceptable salt, solvate or prodrug of said compound or tautomer thereof;
- and
- b) a pharmaceutically acceptable carrier.
9 more elements
Dependencies are inferred from the claim text.