Method of treating cancer using dithiocarbamate derivatives
AssigneeThe Charlotte-Mecklenburg Hospital Authority
InventorThomas Preston Kennedy
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Abstract
Dithiocarbamate, particularly tetraethylthiuram disulfide, and thiocarbamate anions strongly inhibit the growth of cancer cells of a variety of cell types. Such inhibitory effect is enhanced by heavy metal ions such as copper ions, cytokines and ceruloplasmin. A method is presented for using tetraethylthiuram disulfide to reduce tumor growth, and to potentiate the effect of other anticancer agents.
Claims37
A method of treating cancer in humans in need thereof comprising administering a therapeutically effective amount of a dithiocarbamate thiolate anion of the following formula to said humans:
- wherein R2 and R3 are the same or different and represent hydrogen, or unsubstituted or substituted alkyl, akenyl, aryl, alkoxy, or heteroaryl groups;
- M is an alkali metal selected from the group consisting of sodium, potassium, calcium, magnesium, barium, and lithium;
- and n is the valence of the alkali metal.
A method of treating cancer in humans in need thereof comprising administering a therapeutically effective amount of a dithiocarbamate thiolate metal complex of the following formula to said humans:
- wherein R2 and R3 are the same or different and represent hydrogen, or unsubstituted or substituted alkyl, akenyl, aryl, alkoxy, or heteroaryl groups;
- M is a heavy metal selected from the group consisting of arsenic, bismuth, gallium, manganese, selenium, zinc, titanium, vanadium, chromium, iron, cobalt, nickel, copper, silver, silver, and gold;
- An is an anion selected from the group consisting of chloride, bromide, iodide, acetate and other organic or inorganic pharmaceutically acceptable anions;
- and n is the valence of the metal.
A method for treating asthma or arthritis in humans in need thereof comprising administering a therapeutically effective amount of a dithiocarbamate thiolate anion of the following formula to said humans:
- wherein R2 and R3 are the same or different and represent hydrogen, or unsubstituted or substituted alkyl, akenyl, aryl, alkoxy, or heteroaryl groups;
- M is an alkali metal selected from the group consisting of from the group consisting of sodium, potassium, calcium, magnesium, barium, and lithium;
- and n is the valence of the alkali metal.
A method for treating asthma or arthritis in humans in need thereof comprising administering a therapeutically effective amount of a dithiocarbamate thiolate metal complex of the following formula to said humans:
- wherein R2 and R3 are the same or different and represent hydrogen, or unsubstituted or substituted alkyl, akenyl, aryl, alkoxy, or heteroaryl groups;
- M is a heavy metal selected from the group consisting of arsenic, bismuth, gallium, manganese, selenium, zinc, titanium, vanadium, chromium, iron, cobalt, nickel, copper, silver, silver, and gold;
- An is an anion selected from the group consisting of chloride, bromide, iodide, acetate and other organic or inorganic pharmaceutically acceptable anions;
- and n is the valence of the metal.
Dependencies are inferred from the claim text.