Propionic acid derivatives

Compounds of the general formula (I)

• in which
• A represents a bond or represents a —CH2— or —CH2CH2— group,
• X represents O, S or CH2,
• R1, R2 and R3 are identical or different and independently of one another each represents hydrogen, (C1-C6)-alkyl, (C3-C7)-cycloalkyl, hydroxyl, (C1-C6)-alkoxy, (C6-C10)-aryloxy, halogen, trifluoromethyl, trifluoromethoxy, (C1-C6)-alkylaminosulphonyl, nitro or cyano, or
• R1 and R2 are attached to two adjacent carbon atoms and together with these form a fused cyclohexane or benzene ring, the latter optionally being substituted by a (C1-C4)-alkylsulphonylmethyl group, and
• R3 is as defined above,
• R4 represents hydrogen or (C1-C4)-alkyl,
• R5 and R6 together with the carbon atom to which they are attached form a carbonyl group,
• R7 represents hydrogen, (C1-C6)-alkyl, phenyl or benzyl, where the aromatic radicals mentioned for their part may in each case be mono- to trisubstituted by identical or different substituents from the group consisting of (C1-C6)-alkyl, (C1-C6)-alkoxy, hydroxyl and halogen,
• R8 represents furanylmethyl which optionally may be mono- to trisubstituted by identical or different substituents from the group consisting of halogen, hydroxyl, (C1-C6)-alkyl, (C1-C6)-alkoxy, trifluoromethyl, trifluoromethoxy, cyano, nitro and amino,
• R9 and R10 are identical or different and independently of one another each represents hydrogen, (C1-C6)-alkyl, (C1-C6)-alkoxy, trifluoromethyl, trifluoromethoxy or halogen,
• R11 and R12 are identical or different and independently of one another each represents hydrogen or (C1-C6)-alkyl or together with the carbon atom to which they are attached form a (C4-C7)-cycloalkyl ring, and
• R13 represents hydrogen, and their pharmaceutically acceptable salts, hydrates and solvates.