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US 6,548,535 B2Granted
Method for treating ocular hypertension
AssigneeMerck & Co., Inc.
InventorsMaria L. Garcia, Gregory J. Kaczorowski, Owen B. McManus
Life of this patent
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Abstract
This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions related to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of a mammalian species, particularly humans.
Claims4
A method for treating ocular hypertension or glaucoma which comprises administering to a patient in need of such treatment a therapeutically effective amount of a compound of Formula I:
- or a pharmaceutically acceptable salt, enantiomer, diastereomer or mixture thereof:
- wherein,
- R1 is:
- R2 is:
- (a) CO2C1-6alkyl,
- (b) H,
- (c) OH, or
- R2 and R7 are taken together to form an oxirane ring when b is a single bond;
- R3 is:
- (a) H, or
- (b) (C═O)OC1-6alkyl;
- R5 is:
- (a) H,
- (b) OH, or
- (c) OC1-6alkyl;
- R7 is H, OC1-6 alkyl or R7 and R2 are taken together to form an oxirane ring when b is a single bond;
- Y is:
- (a) H,
- (b) OH,
- (c) OC1-6alkyl,
- or Y and R8 are joined such that one of the following rings is formed:
- R8 is C1-10 alkyl or C2-10 alkenyl;
- and
- _____ is a double bond optionally present at a or b or at both a and b.
21 more elements
Dependencies are inferred from the claim text.