Method for cancer therapy

A method of treating a patient suffering with cancer comprising administering to the patient:

• (i) a first component consisting of pharmaceutical composition containing as an active ingredient a compound of formula:
• or a pharmaceutically acceptable salt or ester of said compound,
• wherein the compound of formula II is administered in an amount of from about 76 mg/m2 per day to about 214 mg/m2 per day for up to about 14 days starting on the first day of a 28 day cycle, and
• (ii) a second component consisting of an injection solution containing as an active ingredient paclitaxel which is administered in amount of from about 135 mg/m2 to about 250 mg/m2 on the first day of a 28 day cycle, said 28 day cycle being repeated as long as the tumor remains under control.

A method of treating a patient suffering with cancer comprising administering to the patient:

• (i) a first component consisting of pharmaceutical composition containing as an active ingredient a compound of formula:
• or a pharmaceutically acceptable salt or ester of said compound,
• wherein the compound of formula II is administered in an amount of from about 114 mg/m2 per day to about 320 mg/m2 per day for up to about 7 days starting on the first day of a 28 day cycle, and
• (ii) a second component consisting of an injection solution containing as an active ingredient paclitaxel which is administered in amount of from about 150 mg/m2 to about 200 mg/m2 on the first day of a 28 day cycle, and said 28 day cycle being repeated as long as the tumor remains under control.

A method of treating a patient suffering with cancer comprising administering to the patient:

• (i) a first component consisting of pharmaceutical composition containing as an active ingredient a compound of formula:
• or a pharmaceutically acceptable salt or ester of said compound,
• wherein the compound of formula II is administered in an amount of from about 200 mg/m2 per day to about 560 mg/m2 per day for up to about 4 days starting on the first day of a 21 day cycle, and
• (ii) a second component consisting of an injection solution containing as an active ingredient paclitaxel which is administered in amount of from about 150 mg/m2 to about 200 mg/m2 on the first day of a 21 day cycle, and said 21 day cycle being repeated as long as the tumor remains under control.

A method of treating a patient suffering with cancer comprising administering to the patient:

• (i) a first component consisting of pharmaceutical composition containing as an active ingredient a compound of formula:
• or a pharmaceutically acceptable salt or ester of said compound,
• wherein the compound of formula II is administered in an amount of from about 200 mg/m2 per day to about 560 mg/m2 per day for up to about 4 days starting on the first day of a 21 day cycle, and
• (ii) a second component consisting of an injection solution containing as an active ingredient paclitaxel which is administered in amount of from about 67 mg/m2 to about 125 mg/m2 on the first and eighth day of a 21 day cycle, said 21 day cycle being repeated as long as the tumor remains under control.

A kit comprising:

• (a) a first component containing one or more oral unit dosage forms of an active ingredient, each unit containing about 50 mg to about 200 mg of the active ingredient, wherein the active ingredient is a compound selected from formula I
• or a pharmaceutically acceptable salt or ester said compound, wherein
• R1 is selected from the group consisting of —H, —CH3, and —CH2OH, and
• R2 is —CH3;
• and
• (b) a second component containing a vial or series of vials, each vial containing a single injectable solution dose or multiple injectable solution doses, each dose containing as an active ingredient about 30 mg to about 400 mg of paclitaxel.