Pyridoxine and pyridoxal analogues: novel uses
AssigneeMedicure International Inc.
InventorWasimul Haque
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Abstract
The invention provides pyridoxal and pyridoxine analogues, pharmaceutical compositions containing pyridoxine and pyridoxal analogues, and methods of administering pharmaceutical compositions containing a therapeutically effective amount of at least one of these analogues. In accordance with the present invention, the pyridoxal and pyridoxine analogues can be used in the treatment of undesired platelet aggregation, and in the treatment of symptoms thereof.
Claims8
A method of reducing platelet aggregation in a mammalian patient comprising administering a therapeutically effective amount of a compound of Formula V:
- or a pharmaceutically acceptable acid addition salt thereof, wherein:
- R5 is CH2OH or CHO;
- R1 is
- n is an integer of 1 to 5;
- R2, R3, and R4 are each independently
- hydrogen;
- alkyl;
- aryl or biaryl,
- wherein the aryl or biaryl can be substituted with a cyano, alkyl, alkoxy, amino, hydroxy, halo, nitro, or alkanoyloxy;
- amino;
- acylamino;
- anilino,
- wherein the aniline ring can be substituted with a cyano, alkyl, alkoxy, amino, hydroxy, halo, nitro, or alkanoyloxy;
- nitro;
- or
- guanidino.
The method of claim Wherein the compound is
Dependencies are inferred from the claim text.