Oxindole inhibitors of factor Xa

A compound of formula I:

• wherein:
• A is a member selected from the group consisting of:
• where R6, R7, R8, and R9 are independently selected from the group consisting of H, —OH, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, C3-8cycloalkyl and C6-12carbocyclic aryl;
• m is an integer from 0-3;
• Z is a member selected from the group consisting of a direct link, C1-8alkyl, C3-8cycloalkyl, C2-8alkenyl, C2-8alkynyl, C1-8carbocyclic aryl, or a five to ten membered heterocyclic ring system containing 1-4 nitrogen atoms;
• n is an integer from 0-3;
• D is a member selected from the group consisting of a direct link, —O—, —NR2—, —C(═O)—, —S—, —SO2—, —SO2—NR2—, —NR2—SO2—, —OC(═O)—, —C(═O)O—, —C(═O)—NR2— and —NR2—C(═O)—;
• each R1 is a member independently selected from the group consisting of H, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, C3-8cycloalkyl, halogen, polyhaloalkyl, C0-8alkyl-C(═O)OH, C0-8alkyl-C(═O)O—C1-8alkyl, —CN, —NO2, C0-8alkyl-OH, C0-8alkyl-SH, —OR2 and —O—C(═O)R2, an unsubstituted amino group, a mono- or di-substituted amino group, wherein the substituted amino groups are independently substituted by at least one member selected from the group consisting of H, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, C3-8cycloalkyl, polyhaloalkyl, C0-8alkyl-C(═O)OH and C0-8alkyl-C(═O)O—C1-8alkyl;
• R2 is selected from the group consisting of H, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, C3-8cycloalkyl and C6-12carbocyclic aryl;
• q is an integer from 0-3;
• R11 and R12 are each independently a member selected from the group consisting of H, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, C3-8cycloalkyl, C6-12carbocyclic aryl, C1-6alkylaryl, C1-6alkyl-C3-8cycloalkyl, —OR2, —C(═O)—, —O—C(═O)R2, —C1-8alkyl-OR10, —C1-8alkyl-O—C(═O)R10, —C1-8alkyl-O—C(═O)OR10, —C1-8alkyl-C(═O)NR10R10, —C1-8alkyl-NR10R10, —C1-8alkyl-NR10C(═O)R10, —SR10, where R2 is as set forth above and each R10 is a member independently selected from the group consisting of H, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, aryl and —C(═O)OR2 and wherein when two R10 groups are present they are optionally taken together to form a saturated or unsaturated ring with the atom to which they are both attached, or R11 and R12 are taken together to form an alkenyl double bond substituted by an R10 group, or R11 and R12 collectively form an oxygen atom having a double bond attachment to the ring carbon atom;
• p is an integer from 0-3;
• E is a direct link;
• J is a member selected from the group consisting of a direct link, a bivalent C3-8cycloalkyl group, phenylene and naphthalene;
• G is
• wherein
• R23, R24 and R25 are independently selected from the group consisting of H, —OH, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, C3-8cycloalkyl and C6-12carbocyclic aryl;
• and all pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug compounds thereof.