Dihydrofuro[3,4-b]quinolin-1-one compounds

A compound selected from those of formula (I):

• wherein:
• represents a single or double bond,
• R0 represents hydrogen, hydroxy or linear or branched (C1-C6)alkoxy,
• R1 and R2, which are identical or different, each represents:
• hydrogen,
• linear or branched (C1-C6)alkyl,
• linear or branched (C1-C6)alkoxy,
• hydroxy,
• linear or branched (C1-C6)polyhaloalkyl,
• nitro,
• amino optionally substituted by one or two linear or branched (C1-C6)alkyl groups,
• a group of formula
• wherein m is 1 to 4 inclusive, or form together with the carbon atoms carrying them an aromatic or non-aromatic, mono-or bi-cyclic group having from 5 to 12 ring members, optionally containing 1 or 2 hetero atoms selected from O, S and N,
• R3 represents hydrogen or a group of formula R4 wherein R4 represents:
• aryl,
• heteroaryl,
• (C3-C8)cycloalkyl,
• linear or branched (C1-C6)alkyl optionally substituted by aryl, by heteroaryl, by hydroxy, by linear or branched (C1-C6)alkoxy, or by a group of formula NR5R6 wherein R5 and R6, which are identical or different, each represents linear or branched (C1-C6)alkyl or linear or branched (C1-C6)hydroxyalkyl, or form together with the nitrogen atom carrying them a nitrogen heterocycle,
• or a group of formula COR7, wherein R7 represents one of the following groups:
• aryl,
• linear or branched (C1-C6)alkyl (optionally substituted by a group of formula NR8R9 wherein R8 and R9, which are identical or different, each represents linear or branched (C1-C6)alkyl or linear or branched (C1-C6)hydroxyalkyl, or form together with the nitrogen atom carrying them a nitrogen heterocycle),
• amino optionally substituted by one or more groups aryl, heteroaryl, or linear or branched (C1-C6)alkyl optionally substituted by a group of formula NR8R9 wherein R8 and R9, which are identical or different, each represents linear or branched (C1-C6)alkyl or linear or branched (C1-C6)hydroxyalkyl, or form together with the nitrogen atom carrying them a nitrogen heterocycle,
• or OR10 wherein R10 represents hydrogen or aryl, or linear or branched (C1-C6)alkyl optionally substituted by a group of formula NR8R9 wherein R8 and R9, which are identical or different, each represents linear or branched (C1-C6)alkyl or linear or branched (C1-C6)hydroxyalkyl, or form together with the nitrogen atom carrying them a nitrogen heterocycle,
• X represents oxygen or sulphur or —CH2— or —CH2—CH2—,
• Ar represents aryl, heteroaryl or aryl-(C1-C6)alkyl in which alkyl is linear or branched, it being understood that a least one of R0, R1, or R2 is other than hydrogen,
• their optical isomers, their hydrates, solvates and also addition salts thereof with a pharmaceutically acceptable acid, wherein aryl is to be understood as phenyl, biphenyl, naphthyl or tetrahydronaphthyl, each of those groups being optionally substituted by one or more identical or different atoms or groups selected from halogen and linear or branched (C1-C6)alkyl, hydroxy, linear or branched (C1-C6)alkoxy, linear or branched (C1-C6)polyhaloalkyl, amino (optionally substituted by one or more linear or branched (C1-C6)alkyl groups), nitro, linear or branched (C1-C6)acyl and (C1-C2)alkylenedioxy, heteroaryl is to be understood as an aromatic, mono- or bi-cyclic group having from 5 to 12 ring members and containing one, two or three hetero atoms selected from oxygen, nitrogen and sulphur, wherein the heteroaryl group may be optionally substituted by one or more identical or different atoms or groups selected from halogen and linear or branched (C1-C6)alkyl, hydroxy, linear or branched (C1-C6)alkoxy, linear or branched (C1-C6)polyhaloalkyl, and amino (optionally substituted by one or more linear or branched (C1-C6)alkyl groups), and a nitrogen heterocycle is to be understood as a saturated monocyclic group having from 5 to 7 ring members and containing one, two or three hetero atoms, one of which is nitrogen while the additional hetero atoms(s) optionally present is/are selected from oxygen, nitrogen and sulphur.