Use of PDE V inhibitors for improved fecundity in mammals
AssigneePfizer Inc.
InventorsSimon Lempriere Westbrook, Johannes Fridrich Zanzinger
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Abstract
The invention relates to the use of a cyclic guanosine 3′, 5′-monophosphate phosphodiesterase type five (cGMP PDE V) inhibitor for increasing fecundity in a mammal by one or more of (a) promoting the growth of an oocyte, zygote, blastocyst, embryo and/or foetus, (b) increasing the rate or probability of survival of an embryo and/or foetus and (c) increasing the birth weight of a progeny, or for increasing milk productivity.
Claims9
A method of treatment which comprises administering a therapeutically effective amount of a cyclic guanosine 3′, 5′-monophosphate phosphodiesterase type five (cGMP PDE V) inhibitor, to a female mammal, in order to increase fecundity, by one or more of (a) promoting the growth of an oocyte, zygote, blastocyst, embryo and/or foetus, (b) increasing the rate or probability of survival of an embryo and/or foetus and (c) increasing the birth weight of a progeny.
A method of increasing milk production in a female mammal by administration of a PDE V inhibitor to said mammal.
A method of treatment which comprises administering a therapeutically effective amount of a cyclic guanosine 3′, 5′-monophosphate phosphodiesterase type five (CGMP PDE V) inhibitor, to a female mammal, in order to increase the survival rate or growth rate of a neonate.
A method of increasing milk production in a female mammal which comprises treating said mammal with an effective amount of a PDE V inhibitor.
Dependencies are inferred from the claim text.