Dihydro-benzo [B] [1,4] diazepin-2-one derivatives

A compound of formula

• wherein
• R1 is selected from the group consisting of cyano,
• fluoro-lower alkyl,
• lower alkoxy,
• fluoro-lower alkoxy,
• unsubstituted pyrrol-1-yl, and pyrrol-1-yl substitued by between one to three substituents selected from the group consisting of
• fluoro, chloro, cyano, unsubstituted phenyl, or phenyl substituted by a substituent selected from the group consisting of halogen,
• —(CH2)1-4-hydroxy, fluoro-lower alkyl, lower alkyl, —(CH2)n-lower alkoxy,
• —(CH2)n—C(O)O—R″, —(CH2)1-4—NR′R″, hydroxy-lower alkoxy and
• —(CH2)n—CONR′R″;
• R2 is selected from the group consisting of
• halogen,
• hydroxy,
• lower alkyl,
• fluoro-lower alkyl,
• lower alkoxy,
• hydroxymethyl,
• hydroxyethoxy,
• lower alkoxy-(ethoxy)m, wherein m=1 to 4,
• lower alkoxymethyl,
• cyanomethoxy,
• morpholine-4-yl,
• thiomorpholine-4-yl,
• 1-oxothiomorpholine-4-yl,
• 1,1-dioxothiomorpholine-4-yl,
• 4-oxo-piperidine-1-yl
• 4-alkoxy-piperidine-1-yl,
• 4-hydroxy-piperidine-1-yl,
• 4-hydroxyethoxy-piperidine-1-yl,
• 4-lower alkyl-piperazine-1-yl,
• alkoxycarbonyl,
• 2-dialkylamino-ethylsulfanyl,
• N,N-bis lower alkylamino lower alkyl,
• carbamoylmethyl,
• alkylsulfonyl
• lower alkoxycarbonyl-lower alkyl,
• alkylcarboxy-lower alkyl,
• carboxy-lower alkyl,
• alkoxycarbonylmethylsulfanyl,
• carboxymethylsulfanyl,
• 1,4-dioxa-8-aza-spiro[4.5]dec-8-yl,
• carboxy-lower alkoxy,
• cyano-lower alkyl,
• 2,3-dihydroxy-lower alkoxy,
• carbamoylmethoxy,
• 2-oxo-[1,3]-dioxolan-4-yl-lower alkoxy,
• N-(2-hydroxy-lower alkyl)-N-lower alkyl amino,
• hydroxycarbamoyl-lower alkoxy,
• 2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5c]-pyrrol-5-yl,
• lower alkoxy-carbamoyl-lower alkoxy,
• 3R-hydroxy-pyrrolidin-1-yl,
• 3,4-dihydroxy-pyrrolidin-1-yl,
• 2-oxo-oxazolidin-3-yl,
• lower alkyl-carbamoylmethoxy,
• aminocarbamoyl-lower alkoxy, and, when R1 is unsubstituted pyrrol-1-yl or
• pyrrol-1-yl substituted as defined above, hydrogen;
• Y is —CH═ or ═N—;
• R3 is halogen,
• lower alkyl,
• fluoro-lower alkyl,
• lower alkoxy,
• cyano,
• —(CH2)n—C(O)—OR″,
• —(CH2)n—C(O)—NR′R″,
• or is an unsubstituted five-membered aromatic heterocycle or a five-membered aromatic heterocycle, substituted by halogen, fluoro-lower alkyl, fluoro-lower alkoxy, cyano, —(CH2)n—NR′R″, —(CH2)n—C(O)—OR″, —(CH2)n—C(O)—NR′R″, —(CH2)n—SO2—NR′R″, —(CH2)n—C(NH2)═NR″, hydroxy, lower alkoxy, lower alkylthio, lower alkyl, or lower alkyl substituted by fluoro, hydroxy, lower alkoxy, cyano or carbamoyloxy;
• R′ is selected from the group consisting of hydrogen,
• lower alkyl,
• C3-C6-cycloalkyl,
• fluoro-lower alkyl and
• 2-lower alkoxy lower alkyl;
• R″ is selected from the group consisting of hydrogen,
• lower alkyl,
• C3-C6-cycloalkyl,
• fluoro-lower alkyl,
• 2-lower alkoxy lower alkyl,
• —(CH2)2-4-di-lower alkylamino,
• —(CH2)2-4-morpholinyl,
• —(CH2)2-4-pyrrolidinyl,
• —(CH2)2-4-piperidinyl and
• 3-hydroxy-lower alkyl;
• and
• n is 0, 1, 2, 3 or 4;
• or a pharmaceutically acceptable addition salt thereof.