Vitamin D3 derivative and treating agent for inflammatory respiratory disease using same

A vitamin D3 compound expressed by the following general formula (1) or pharmaceutically permissible solvates thereof,

• wherein, R01 and R02 are each independently a hydrogen atom, a trimethylsilyl group, a triethylsilyl group, a t-butyldimethylsilyl group, an acetyl group, a methoxymethyl group or a tetrahydro-4H-pyran-2-yl group;
• Z is one out of the following formulae (1-1) and (1-2),
• in the above formulae (1-1) and (1-2),
• m is an integer of 0 to 2;
• n is 0;
• X′ is NH;
• R11 and R12 are identical to or different from each other, and express a hydrogen atom or a C1-C4 alkyl group;
• K, L and M are each a hydrogen atom;
• M is a hydrogen atom, and K and L together express a single bond and express a double bond in cooperation with the single bond already shown in the formula;
• or K is a hydrogen atom, and L and M together express a single bond and express a double bond in cooperation with the single bond already shown in the formula;
• R21, R22 and R23 are identical to or different from each other, and they are a hydrogen atom, a hydroxy group, a carboxyl group, a trifluoromethyl group, a pentafluoroethyl group, a C1-C4 alkyloxycarbonyl group, a C2-C5 acyloxy group, a C1-C4 alkyloxy group or a C1-C4 alkyl group which may be substituted with a hydroxyl group, a C2-C5 acyloxy group or a alkyloxy group, or R21 and R22 together may express a C3-C6 cyclic alkyl group in cooperation with the carbon atom to which they are bonded,
• with the proviso that the following compound (a) is excluded,
• (a) a compound in which R21 and R22 are both hydroxy groups, both alkyloxy groups, or a hydroxy group and an alkyloxy group.