Pharmaceutical dopamine glycoconjugate compositions and methods of their preparation

A method for preparing a pharmaceutical composition comprising the step of adding one or more of additives, stabilizers, carriers, binders, buffers, excipients, fillers, emollients, disintegrants, lubricating agents, or antimicrobial agents to a hydrophilic transportable dopaminergic prodrug compound according to FORMULA V,

• wherein,
• Ring 1 is an aryl ring having 4 to 8 carbon atoms, among which atoms are counted “X” and “Y”;
• each of X and Y is optional;
• X, when present, is either —C(R1)2— or —C(R1)2—C(R1)2—;
• Y, when present, is either —CH2— or —CH2—CH2—;
• z, R5, and R5′ are optional, and when present, z, R5, and R5′ together form a lower alkyl moiety or a substituted lower alkyl moiety;
• N is part of either an amine or an amide linkage;
• E is a ribosyl or glucosyl saccharide which is bonded to N through a single bond from a carbon atom thereof;
• R1 and R4 are selected from the group consisting of hydrogen, hydroxyl, halogen, halo-lower alkyl, alkoxyl, alkoxy-lower alkyl, halo-alkoxy, thioamido, amidosulfonyl, alkoxylcarbonyl, carboxamide, aminocarbonyl, and alkylamino-carbonyl;
• R2 and R3 are hydroxyl;
• R5 and R5′, when present, are selected from the group consisting of hydrogen, hydroxyl, alkoxyl, carboxyl, alkoxylcarbonyl, aminocarbonyl, alkylamino-carbonyl, and dialkylamino-carbonyl;
• and
• R6 and R6′ are selected from the group consisting of hydrogen, hydroxyl, alkoxyl, carboxyl, alkoxylcarbonyl, aminocarbonyl, alkylamino-carbonyl, and dialkylamino-carbonyl.