Effectors of dipeptidyl peptidase IV
AssigneeProbiodrug AG
InventorsHans-Ulrich Demuth, Konrad Glund, Dagmar Schlenzig, Susanne Kruber
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Abstract
Dipeptide compounds and compounds analogous to dipeptide compounds that are formed from an amino acid and a thiazolidine or pyrrolidine group, and salts thereof used in the treatment of impaired glucose tolerance, glycosuria, hyperlipidaemia, metabolic acidoses, diabetes mellitus, diabetic neuropathy and nephropathy and also of sequelae of diabetes mellitus in mammals.
Claims14
A pharmaceutical composition for the treatment of metabolic disorders comprising:
- a salt form of a dipeptide compound formed from an amino acid and a thiazolidine or pyrrolidine group, in combination with pharmaceutically acceptable carriers or solvents, wherein said salts are selected from the group consisting of acetates, succinates, tartrates, fumarates, phosphates and sulphates.
A pharmaceutical composition comprising dipeptide compounds and analogs thereof that are selected from the salts of the group consisting of L-threo-isoleucyl pyrroldine, L-allo-isoleucyl thiazolidine, L-allo-isoleucyl pyrrolidine in combination with pharmaceutically acceptable carriers or solvents, wherein said salts are selected from the group consisting of acetates, succinates, tartrates, fumarates, phosphates and sulphates.
Dependencies are inferred from the claim text.