Virginiamycin mixture
AssigneePfizer Inc.
InventorsJames W. Carson, Frederic W. Chapin, Charles H. Fahrenholz
Life of this patent
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Abstract
A mixture comprising: a) virginiamycin; b) a pharmaceutically acceptable and substantially anhydrous wetting agent including sodium lauryl sulfate; c) a sufficient amount of pharmaceutically acceptable buffering agent to provide a pH of from about 3 0 to about 7.0 when said mixture is added to water; and d) from about 0.5 weight percent to about 10 0 weight percent colloidal silicon dioxide, wherein the ratio of the weight percent of (b) to the weight percent of (a) percent by weight is at least about 1.5:1. The mixture is designed to be added to water to produce a stable suspension of the virginiamycin, which can then be applied to, for example, feed grain.
Claims45
A mixture comprising:
- a) virginiamycin;
- b) a pharmaceutically acceptable surfactant;
- c) a sufficient amount of a pharmaceutically acceptable buffering agent to provide a pH of from about 3.0 to about 7.0 when said mixture is added to water;
- and
- d) from about 0.5 weight percent to about 10.0 weight percent colloidal silicon dioxide,
- wherein the ratio of the weight percent of (b) to the weight percent of (a) is at least about 1.5:1.
A substantially anhydrous mixture comprising:
- a) virginiamycin;
- b) a pharmaceutically acceptable and substantially anhydrous surfactant;
- c) a sufficient amount of a pharmaceutically acceptable buffering agent to provide a pH of from about 3.0 to about 7.0 when said mixture is added to water;
- and
- d) from about 0.5 weight percent to about 10.0 weight percent colloidal silicon dioxide,
- wherein the ratio of the weight percent of (b) to the weight percent of (a) is at least about 1.5:1.
A substantially anhydrous mixture comprising:
- a) virginiamycin;
- b) a pharmaceutically acceptable and substantially anhydrous surfactant;
- c) a sufficient amount of a pharmaceutically acceptable buffering agent to provide a pH of from about 3.0 to about 7.0 when said mixture is added to water;
- d) from about 0.5 weight percent to about 10.0 weight percent colloidal silicon dioxide;
- e) a pharmaceutically acceptable anti-foaming agent;
- and
- f) a pharmaceutically acceptable dye,
- wherein the ratio of the weight percent of (b) to the weight percent of (a) is at least about 1.5:1.
Feed grain treated with a water suspension of a mixture comprising:
- a) virginiamycin;
- b) a pharmaceutically acceptable surfactant;
- c) a sufficient amount of a pharmaceutically acceptable buffering agent to maintain said suspension at pH of from about 3.0 to about 7.0;
- d) from about 0.5 weight percent to about 10.0 weight percent colloidal silicon dioxide,
- wherein the ratio of the weight percent of (b) to the weight percent of (a) is at least about 1.5:1.
A method of treating feed grain with virginiamycin, comprising
- (1) forming a mixture including:
- a) virginiamycin,
- b) a pharmaceutically acceptable surfactant,
- c) a sufficient amount of a pharmaceutically acceptable buffering agent to provide a pH of from about 3.0 to about 7.0 when the mixture is added to water, and
- d) from about 0.5 weight percent to about 10.0 weight percent colloidal silicon dioxide,
- wherein the ratio of the weight percent of (b) to the weight percent of (a) is at least about 1.5:1;
- (2) suspending the mixture in water to form a suspension;
- and
- (3) applying the suspension to feed grain.
Dependencies are inferred from the claim text.