Geminin gene and protein
AssigneePresident and Fellows of Harvard College
InventorsThomas J. McGarry, Kristen Kroll, Marc W. Kirschner
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Abstract
The claimed invention pertains to a novel protein called Geminin which is able to inhibit DNA replication and/or induce neurogenesis. The claimed invention includes the amino acid sequence, the nucleic acid sequence, and various domains thereof. The invention further relates to methods for treating patients with a proliferative disease by administering an effective amount of the Geminin protein and/or nucleic acid. Similarly, the claimed inventions pertains to methods for treating various neurological disorders by administering neuronal cells which were differentiated by exposure to Geminin.
Claims10
A plasmid or vector comprising the nucleic acid sequence of SEQ ID NO.:
- 4 or 20, or the complement of SEQ ID NO.:
- 4 or 20.
A cell transfected with a nucleic acid of SEQ ID NO.:
- 4 or 20, or the complement of SEQ ID NO.:
- 4 or 20.
An isolated nucleic acid molecule that comprises a nucleic acid sequence that encodes SEQ ID NO.:
- 8 or 24.
A plasmid or vector comprising a nucleic acid sequence that encodes SEQ ID NO.:
- 8 or 24.
A cell transfected with a nucleic acid that encodes SEQ ID NO.:
- 8 or 24.
An isolated nucleic acid molecule that comprises a nucleic acid sequence that encodes SEQ ID NO.:
- 8 or 24 having a non-functional, mutated or deleted destruction box sequence.
An isolated nucleic acid molecule that comprises:
- a) a nucleic acid sequence of SEQ ID NO:
- 4 or 20;
- or
- b) the complementary strand of a).
An isolated nucleic acid sequence that encodes SEQ ID NO.:
- 4 or 20, wherein the nucleic acid is RNA.
Dependencies are inferred from the claim text.