Membrane-bound metalloprotease and soluble secreted form thereof
AssigneesJCR Pharmaceuticals Co., Ltd., Masafumi Matsuo
InventorsMasafumi Matsuo, Koji Ikeda, Noriaki Emoto, Sunu Budhi Raharjo, Yudha Nurhantari, Kayoko Saiki, Mitsuhiro Yokoyama
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Abstract
Disclosed are metalloprotease proteins or their salts usable for treatment or prophylaxis of conformational diseases and for providing a screening kit for selection of carcinostatics and anti-metastatic agents. The metalloprotease proteins have an amino acid sequence set forth under SEQ ID NO:1 or NO:2 in the Sequence Listing. The proteins have a neutral optimal pH, hydrolyze endothelin 1, atrial natriuretic peptide and angiotensin I and are inhibited by 1,10-phenanthroline, phosphoramidon and thiorphan.
Claims9
A protein comprising the amino acid sequence set forth under SEQ ID NO:1 in the Sequence Listing, or a salt thereof.
A protein comprising the amino acid sequence set forth under SEQ ID NO:2 in the sequence Listing, or a salt thereof.
A DNA comprising the coding region nucleotide sequence of SEQ ID NO:3 or NO:4 in the Sequence Listing.
A DNA comprising a nucleotide sequence with one or more nucletides substituted relative to the coding region nucleotide sequence of SEQ ID NO:3 or NO:4 in the Sequence Listing and encoding the protein encoded by the nucleotide sequence set forth under SEQ ID NO:3 or NO:4.
Dependencies are inferred from the claim text.