Gene encoding for a transmembrane protein
AssigneeEiken Kagaku Kabushiki Kaisya
InventorsNobuyoshi Shimizu, Kentaro Nagamine
Life of this patent
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Abstract
A gene for a novel transmembrane protein was isolated and its nucleotide sequence was determined. A protein encoded by this gene (TRPC7) has 7 transmembrane regions, and because there is homology with TRP (transient receptor potential), this protein is considered to have calcium channel functions. Further, since a mutation in the TRPC7 gene is frequently observed in patients with manic-depressives insanity, TRPC7 is considered to be a pathogenic gene for bipolar affective disorder.
Claims11
An isolated polynucleotide comprising a polynucleotide selected from the group consisting of:
- (a) a polynucleotide coding for a polypeptide consisting of amino acids shown in SEQ ID NO:2;
- (b) a polynucleotide resulting from degeneracy of genetic code coding for the same amino acids as in SEQ ID NO:2;
- (c) a polynucleotide complementary to the polynucleotide of (a) or (b);
- and
- (d) a polynucleotide consisting of at least 15 contiguous nucleotides from the polynucleotide of (a), (b), or (c).
An isolated polypeptide comprising the amino acid sequence shown in SEQ ID NO:2.
Dependencies are inferred from the claim text.