DNA encoding human acid-sensing ion channel BNaC4 (ASIC4)
AssigneeOrtho-McNeil Pharmaceutical, Inc.
InventorsAdrienne Elizabeth Dubin, Jayashree Pyati, Rene Huvar, Mark G. Erlander
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Abstract
DNA encoding human acid sensing ion channel BnaC4 has been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
Claims8
An isolated and purified nucleic acid molecule selected from the group consisting of:
- a) a polynucleotide having a nucleotide sequence set forth in SEQ ID NO:
- 6;
- b) a polynucleotide having a nucleotide sequence set forth in SEQ ID NO:
- 7;
- and
- c) a polynucleotide that is complementary to the polynucleotide sequence of (a).
An expression vector comprising a recombinant polynucleotide encoding a protein comprising the amino acid sequence set forth in SEQ ID NO:
- 9.
Dependencies are inferred from the claim text.