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AssigneeMillennium Pharmaceuticals, Inc.
InventorsLouis A. Tartaglia, Robert I. Tepper, Janice A. Culpepper
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The present invention relates to the discovery, identification and characterization of nucleotides that encode Ob receptor (ObR), a receptor protein that participates in mammalian body weight regulation. The invention encompasses obR nucleotides, host cell expression systems, ObR proteins, fusion proteins, polypeptides and peptides, antibodies to the receptor, transgenic animals that express an obR transgene, or recombinant knock-out animals that do not express the ObR, antagonists and agonists of the receptor, and other compounds that modulate obR gene expression or ObR activity that can be used for diagnosis, drug screening, clinical trial monitoring, and/or the treatment of body weight disorders, including but not limited to obesity, cachexia and anorexia.
An isolated nucleic acid molecule encoding the amino acid sequence of SEQ ID NO. 4.
An isolated nucleic acid molecule comprising the sequence of SEQ ID NO:
An isolated nucleic acid molecule encoding the Ob receptor amino acid sequence encoded by the cDNA of clone fahj5312d (ATCC No. 69963).
An isolated nucleic acid molecule encoding the Ob receptor amino acid sequence encoded by the genomic DNA of clone h-ObR-p87 (ATCC No. 69972).
An isolated nucleic acid molecule comprising a nucleotide sequence which hybridizes to a nucleic acid molecule having the sequence of SEQ ID NO:
An isolated nucleic acid molecule comprising a nucleotide sequence which hybridizes to a nucleic acid molecule having the sequence of the Ob receptor encoding portion of the cDNA of clone fahj5312d (ATCC No. 6993) under conditions of hybridization in 0.5 M NaPO4/7% SDS/1 mM EDTA at 65° C. followed by washing in 0.1×SSC/0.1% SDS at 68° C., wherein said isolated nucleic acid molecule encodes a cell surface receptor polypeptide which is capable of binding leptin and transducing an intracellular signal.
Dependencies are inferred from the claim text.