Methods of measuring tissue factor pathway inhibitor-3
AssigneeHuman Genome Sciences, Inc.
InventorsReiner L. Gentz, Tsu-An Hsu, Craig A. Rosen, Jian Ni
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Abstract
The present invention relates to a novel TFPI-3 protein which is a member of the tissue factor protease inhibitor family. In particular, isolated nucleic acid molecules are provided encoding human TFPI-3 proteins. TFPI-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TFPI-3 activity. Also provided are diagnostic methods for detecting hemostasis system-related disorders and therapeutic methods for treating hemostatis system-related disorders.
Claims32
A method for measuring the amount of TFPI-3 in a sample, comprising contacting said sample to an antibody or fragment thereof with specificity for a polypeptide consisting of amino acids 106 to 156 of SEQ ID NO:2, and assaying for binding of said antibody or fragment thereof.
Dependencies are inferred from the claim text.