Inhibition of molecular and biological processes using modified oligonucleotides
AssigneeFidelity Systems, Inc.
InventorsSergei A. Kozyavkin, Andrei G. Malykh, Nikolai N. Polouchine, Alexei I. Slesarev
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Abstract
A method of inhibiting at least one molecular process in a sample, comprising administering to the sample an oligonucleotide or polynucleotide containing at least one monomeric unit having formula (I): A—Xn (I) wherein A is an organic moiety, n is at least 1, and each X is independently selected from the group consisting of —NRCOCONu, —NHCOCR2CR2CONu, —NHCOCR═CRCONu, and —NHCOSSCONu, wherein each R independently represents H or a substituted or unsubstituted alkyl group, and Nu represents a nucleophile, or a salt of the compound.
Claims22
A method of inhibiting at least one molecular process involving the interaction between nucleic acids in a sample capable of undergoing said at least one molecular process, comprising:
- administering to said sample an oligonucleotide or polynucleotide containing at least one monomeric unit having formula (I):
- A—Xn (I)
- wherein n is at least 1, A is a nucleotide or nucleoside having a ribose or deoxyribose sugar, wherein each X is attached to a carbon atom of the ribose or deoxyribose sugar, or A is not a nucleotide or nucleoside, and each X is independently selected from the group consisting of —NRCOCONu, —NHCOCR2CR2CONu, —NHCOCR═CRCONu, and —NHCOSSCONu, wherein each R independently represents H or a substituted or unsubstituted alkyl group, and Nu represents a nucleophile.
Dependencies are inferred from the claim text.