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AssigneeNew York Blood Center, Inc.
InventorsBernard Horowitz, Bolanle Williams, Henrietta Margolis-Nunno, Sing N. Chin
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The present invention concerns the product produced by inactivating extracellular or intracellular pathogenic virus in a biological composition without incurring substantial disruption or inactivation of cells and without significant loss of labile proteins or other valuable biological components also contained therein, the inactivation process comprising subjecting said composition to a virucidally effective amount of irradiation in the presence of (a) a mixture of a compound that quenches type I photodynamic reactions and a compound that quenches type II photodynamic reactions or (b) a bifunctional compound that is capable of quenching both type I and type II reactions, to thereby inactivate said virus while retaining functionality of said composition. The composition is advantageously subjected to the irradiation and the mixture of compounds or bifunctional compound in the presence of an irradiation sensitizer. Moreover, the process can be advantageously combined with a different virucidal method to enhance virus inactivation.
A process for inactivating an extracellular or intracellular virus which may be present in a biological composition, said biological composition comprising at least one of a cell-containing biological composition and a biological fluid composition, said process comprising subjecting said biological composition to a virucidally effective amount of artificial irradiation, in the presence of (a) a mixture of at least one quencher compound that quenches type I photodynamic reactions and at least one quencher compound that quenches type II photodynamic reactions, or (b) a quencher compound that quenches both type I and type II reactions, or (c) a mixture of a quencher compound that quenches both type 1 and type II reactions and an additional quencher compound, whereby said quencher compound(s) are present at a concentration effective to substantially maintain, in the case of said cell-containing biological composition, at least 70% of structural integrity of cells in said cell-containing biological composition and in the case of said biological fluid composition, at least 75% of activity of said biological fluid composition.
Dependencies are inferred from the claim text.