Attenuated strains of mycobacteria
AssigneeAventis Pasteur Limited
InventorsBruno Flesselles, Michel H. Klein
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Abstract
Attenuated strains of Mycobacterium, particularly species of the tuberculosis complex, have the mycobacterial cell entry (mce) gene functionally disabled. The gene may be disabled by an insertion into the gene which disrupts the mycobacterial cell entry function thereof of a selectable marker which is used for screen for homologous recombinants in which a double cross-over event has been effected. The attenuated strains may be used in the immunization of hosts against Mycobacterium disease.
Claims5
A method of generating an immune response in a host comprising administering thereto an immunoeffective amount of an immunogenic composition comprising a strain of Mycobacterium wherein the mycobacterial cell entry (mce) gene is functionally disabled, said strain of Mycobacterium being selected from the group consisting of Mycobacterium tuberculosis and Mycobacterium bovis.
Dependencies are inferred from the claim text.