Antigenic constructs of major histocompatibility complex class I antigens with specific carrier molecules, the preparation and use thereof
OwnerGerhard Seeman, Klaus Bosslet +1inventors
InventorsGerhard Seeman, Klaus Bosslet, Hans Harald Sedlacek
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Abstract
Antigenic constructs which result from linkage of major histocompatibility complex (MHC) class I antigens with specific carrier molecules are described. The linkage is effected N- or C-terminally by covalent bonding or, for example, in the case of non-covalent bonding by an avidin/biotin bridge. The specific carrier molecules bind selectively to target cells and are preferably monoclonal antibodies. Processes of genetic manipulation for the preparation of such constructs are indicated. Antigenic constructs according to the invention are used to damage or eliminate target cells.
Claims10
An antigenic construct comprising a cytotoxic T cell stimulating allogenic major histocompatibility complex (MHC) class I antigen linked at its C-terminal or N-terminal end to a target-cell-specific carrier molecule, wherein said construct can be used to activate cytotoxic T cells.
An antigenic construct comprising a cytotoxic T cell stimulating allogenic major histocompatibility complex (MHC) class I antigen linked at its N-terminal end to a target-cell-specific carrier molecule.
An antigenic construct comprising a cytotoxic T cell stimulating allogenic major histocompatibility complex (MHC) class I antigen linked at its C-terminal end to a target-cell-specific carrier molecule.
Dependencies are inferred from the claim text.