US 6,548,066 B1 · Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors

Abstract

The invention concerns immunogens, immunogenic compositions and method for the treatment of gastrin-dependent tumors. The immunogens comprise a peptide from the CCK-B/gastrin-receptor conjugated to a spacer and to an immunogenic carrier. The immunogens are capable of inducing antibodies in vivo which bind to the CCK-B/gastrin-receptor in tumor cells, thereby preventing growth stimulating peptide hormones from binding to the receptors, and inhibiting tumor cell growth. The immunogens also comprise antibodies against the CCK-B/gastrin-receptor for passive immunization. The invention also concerns diagnostic methods for detecting gastrin-dependent tumors in vivo or from a tissue biopsy using the antibodies of the invention.

Claims9

Dependent claims

An immunogen comprising:

a human CCK-B/gastrin receptor-immunomimic peptide consisting of the amino acid sequence KLNRSVQGTGPGPGASL (SEQ ID NO:
1) or GPGAHRALSGAPISF (SEQ ID NO:
2) linked at one of its ends to a spacer peptide conjugated to an immunogenic carrier.

Dependencies are inferred from the claim text.

Facts

Application

09/076,372Filed 12 May 1998 · us provisional application

Priority

12 May 1997

Granted

15 Apr 2003

Term ends

Not estimatedThe source records don’t support an estimate.

Classification17 codes

C07K 14/72
Receptors; Cell surface antigens; Cell surface determinants: for hormones
A61K 39/0005
Medicinal preparations containing antigens or antibodies: vertebrate antigens
A61K 39/001102
Cancer antigens: receptors, cell surface antigens or cell surface determinants
A61P 35/00
Antineoplastic agents

Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors

Life of this patent

Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors

Life of this patent

Abstract

Claims9