Isolated peptides consisting of amino acid sequences found in SSX or NY-ESO-1 molecules, which bind to HLA molecules
AssigneeLudwig Institute for Cancer Research
InventorsOzlem Tureci, Ugur Sahin, Michael Pfreundschuh, Hans Georg Rammensee, Stefan Stevanovic
Life of this patent
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Abstract
The invention relates to members of the SSX family of genes, as well as their uses. Also a part of the invention are peptides derived from SSX molecules and the NY-ESO-1 molecule, which form complexes with HLA molecules, leading to lysis of cells presenting these complexes, by cytolytic T cells.
Claims6
An isolated peptide consisting of from 8 to 12 amino acids, wherein said amino acids correspond to contiguous amino acids of an SSX molecule or NY-ESO-1, wherein said isolated peptide has a threonine residue or an alanine residue at both its second and terminal positions, and binds to an HLA molecule to form a complex.
An isolated peptide consisting of amino acids 41-49 of the protein encoded by the nucleotide sequence set forth at SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.