Synferon
AssigneeHuman Genome Sciences, Inc.
InventorsHenrik S. Olsen, Reiner L. Gentz, Steven M. Ruben
Life of this patent
Estimating the term…
Abstract
The present invention relates to a novel Synferon protein which is a member of the interferon family. In particular, isolated nucleic acid molecules are provided encoding a synthetic interferon polypeptide, called “Synferon”. Synferon polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Synferon activity. Also provided are therapeutic methods for treating immune system-related disorders.
Claims69
An isolated antibody or fragment thereof that specifically binds to a protein selected from the group consisting of:
- (a) a protein consisting of amino acid residues 2 to 141 of SEQ ID NO:2;
- (b) a protein consisting of amino acid residues 1 to 139 of SEQ ID NO:2;
- (c) a protein consisting of amino acid residues 2 to 139 of SEQ ID NO:2;
- (d) a protein consisting of a portion of SEQ If) NO:2, wherein said portion consists of at least 30 contiguous amino acid residues of SEQ ID NO:2;
- and
- (e) a protein consisting of a portion of SEQ ID NO:2, wherein said portion consists of at least 50 contiguous amino acid residues of SEQ ID NO:2.
An isolated antibody or fragment thereof obtained from an animal that has been immunized with a protein selected from the group consisting of:
- (a) a protein comprising the amino acid sequence of amino acid residues 2 to 141 of SEQ ID NO:2;
- (b) a protein comprising the amino acid sequence of amino acid residues 1 to 139 of SEQ ID NO:2;
- (c) a protein comprising the amino acid sequence of amino acid residues 2 to 139 of SEQ ID NO:2;
- (d) a protein consisting of an amino acid sequence of at least 30 contiguous amino acid residues of SEQ ID NO:2;
- and
- (e) a protein consisting of an amino acid sequence of at least 50 contiguous amino acid residues of SEQ ID NO:2;
- wherein said antibody or fragment thereof specifically binds to said amino acid sequence.
An isolated monoclonal antibody or fragment thereof that specifically binds to a protein selected from the group consisting of:
- (a) a protein consisting of amino acid residues 2 to 141 of SEQ ID NO:2;
- (b) a protein consisting of amino acid residues 1 to 139 of SEQ ID NO:2;
- (c) a protein consisting of amino acid residues 2 to 139 of SEQ ID NO:2;
- (d) a protein consisting of a portion of SEQ ID NO:2, wherein said portion consists of at least 30 contiguous amino acid residues of SEQ ID NO:2;
- and
- (e) a protein consisting of a portion of SEQ ID NO:2, wherein said portion consists of at least 50 contiguous amino acid residues of SEQ ID NO:2.
An isolated antibody or fragment thereof that specifically binds to a protein selected from the group consisting of:
- (a) a protein consisting of the full-length polypeptide encoded by the cDNA contained in ATCC Deposit Number 209522;
- (b) a protein consisting of the full-length polypeptide minus the N-terminal methionine encoded by the cDNA contained in ATCC Deposit Number 209522;
- (c) a protein consisting of a portion of the polypeptide encoded by the cDNA contained in ATCC Deposit Number 209522, where in said portion consists of at least 30 contiguous amino acid residues of the polypeptide encoded by the cDNA contained in ATCC Deposit Number 209522;
- and
- (d) a protein consisting of a portion of the polypeptide encoded by the cDNA contained in ATCC Deposit Number 209522, wherein said portion consists of at least 50 contiguous amino acid residues of the polypeptide encoded by the cDNA contained in ATCC Deposit Number 209522.
An isolated antibody or fragment thereof obtained from an animal that has been immunized with a protein selected from the group consisting of:
- (a) a protein comprising the amino acid sequence of the full-length polypeptide encoded by the cDNA contained in ATCC Deposit Number 209522;
- (b) a protein comprising the amino acid sequence of the full-length polypeptide minus the N-terminal methionine encoded by the cDNA contained in ATCC Deposit Number 209522;
- (c) a protein consisting of an amino acid sequence of at least 30 contiguous amino acid residues of the polypeptide encoded by the cDNA contained in ATCC Deposit Number 209522;
- and
- (d) a protein consisting of an amino acid sequence of at least 50 contiguous amino acid residues the polypeptide encoded by the cDNA contained in ATCC Deposit Number 209522;
- wherein said antibody or fragment thereof specifically binds to said amino acid sequence.
An isolated monoclonal antibody or fragment thereof that specifically binds to a protein selected from the group consisting of:
- (a) a protein consisting of the full-length polypeptide encoded by the cDNA contained in ATCC Deposit Number 209522;
- (b) a protein consisting of the full-length polypeptide minus the N-terminal methionine encoded by the cDNA contained in ATCC Deposit Number 209522;
- (c) a protein consisting of a portion of the polypeptide encoded by the cDNA contained in ATCC Deposit Number 20953, wherein said portion consists of at least 30 contiguous amino acid residues of the polypeptide encoded by the cDNA contained in ATCC Deposit Number 209522;
- and
- (d) a protein consisting of a portion of the polypeptide encoded by the cDNA contained in ATCC Deposit Number 20953, wherein said portion consists of at least 50 contiguous amino acid residues of the polypeptide encoded by the cDNA contained in ATCC Deposit Number 209522.
Dependencies are inferred from the claim text.