Medicinal aerosol formulation
AssigneeAeropharm Technology Incorporated
InventorsAnthony J. Cutie, Akwete L. Adjei, Frederick A. Sexton
Life of this patent
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Abstract
This invention relates to a medicinal aerosol formulation and more particularly, to a medicinal aerosol formulation containing pioglitazone medicament and a fluid carrier.
Claims36
A nonaqueous aerosol formulation, which comprises:
- (a) a therapeutically effective amount of pioglitazone medicament;
- (b) a nonaqueous fluid propellant carrier;
- and
- (c) added thereto, a water addition stabilizer present in an amount which is in addition to nascent formulation water.
A nonaqueous aerosol formulation, which consists essentially of:
- (a) a therapeutically effective amount of a pioglitazone medicament;
- (b) a nonaquecus fluid propellant carrier;
- (c) a second medicament selected from the group consisting of an amylin, an insulin and a mixture of the foregoing;
- and
- (d) added thereto, a water addition stabilizer present in an amount which is in excess of nascent formulation water.
A nonaqueous aerosol formulation, which consists essentially of:
- (a) a therapeutically effective amount of a pioglitazone medicament;
- (b) a nonaqueous fluid propellant carrier;
- (c) a second medicament selected from the group consisting of an amylin, an insulin and a mixture of the foregoing;
- and
- (d) added thereto, a stabilizer comprising a water addition which is in an amount which (1) is in excess of nascent formulation water and (2) is present in an amount sufficient to stabilize the formulation to prevent settling, creaming or flocculation for a time sufficient to allow reproducible dosing of said pioglitazone medicament after agitation of the formulation.
A method of stabilizing a nonaqueous aerosol formulation, comprising (a) a therapeutically effective amount of pioglitazone medicament;
- and (b) a nonaqueous fluid propellant carrier, which comprises:
- adding thereto, a water addition stabilizer present in an amount which is in addition to nascent formulation water.
A metered dose inhaler containing a nonaqueous medicinal aerosol formulation, the formulation comprising:
- (a) a pioglitazone drug in particulate form in a therapeutically effective amount;
- (b) a nonaqueous fluid propellant carrier;
- and
- (c) added thereto, a stabilizer comprising a water addition which is present in an amount which (1) is in excess of nascent formulation water and (2) is present in an amount sufficient to stabilize the formulation to prevent settling, creaming or flocculation for a time sufficient to allow reproducible dosing of said pioglitazone drug after agitation of the formulation.
A metered dose inhaler containing a nonaqueous medicinal aerosol formulation which consists essentially of:
- (a) a pioglitazone drug in particulate form in a therapeutically effective amount combined with a second drug which is selected from the group consisting of an amylin, an insulin and a mixture of the foregoing;
- (b) a nonaqueous fluid propellant carrier;
- and
- (c) added thereto, a stabilizer comprising a water addition present in an amount which is in excess of nascent formulation water.
Dependencies are inferred from the claim text.