Method for producing solvent-free noncrystalline biologically active substances
AssigneeAbbot Laboratories
InventorsJörg Breitenbach, Ulrich Reinhold, Jürgen Zeidler, Jörg Rosenberg
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Abstract
Solvent-free noncrystalline bioactive substances are prepared from the corresponding crystalline bioactive substances in an extruder by melting the substances in the extruder under reduced pressure and in the absence of auxiliaries, cooling and comminuting.
Claims12
A process for preparing a solvent-free noncrystalline bioactive substance from the corresponding solvent-containing bioactive substance crystals in an extruder, wherein the solvent-containing substance crystals are melted in the extruder under reduced pressure, the pressure being reduced in one zone of the extruder, and wherein the substance crystals are employed free of auxiliary substances.
Dependencies are inferred from the claim text.