Cross-linked ultra-high molecular weight polyethylene for medical implant use
AssigneeSmith & Nephew, Inc.
InventorsMarcus L. Scott, Shilesh C. Jani
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Abstract
The present invention relates to the prevention and decrease of osteolysis produced by wear of the ultrahigh molecular weight polyethylene (UHMWPE). Methods are disclosed for the isolation of wear particles, preparation of implants exhibiting decreased wear in comparison to conventional UHMWPE and preparation of implants that cause decreased biological response in comparison to conventional UHMWPE. The implants created by these methods are also included in the present invention.
Claims2
A method of determining an irradiation dose to minimize a macrophage response to a UHMWPE medical implant for use in a body comprising the steps of:
- crosslinking the UHMWPE at an irradiation dose;
- annealing the UHMWPE;
- wear testing the UHMWPE to generate wear particles;
- filtering the wear particles using a filter having a pore size of 0.05 μm or less;
- and
- selecting the irradiation dose that produces a decreased total number of wear particles as compared to conventional UHMWPE.
Dependencies are inferred from the claim text.