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AssigneeEdwards Lifesciences Corporation
InventorsAlain F. Carpentier, Sophie Carpentier, Crystal M. Cunanan, Lillian Quintero, Michael N. Helmus, Christine Loshbaugh, H. Chris Sarner
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A method for fixation of biological tissues, and bioprosthetic devices prepared by such method. The method generally comprises the steps of A) fixing the tissue, B) treating the tissue with a mixture of i) a denaturant, ii) a surfactant and iii) a crosslinking agent, C) fabricating or forming the bioprosthesis (e.g., forming the tissue and attaching any non-biological components thereto) and D) subjecting the bioprosthesis to terminal sterilization.
A method for forming a bioprosthesis including treatment of biological tissue which contains connective tissue protein to reduce the potential for post-implantation calcification and thrombogenicity, said method comprising the steps of:
A method for treatment of biological tissue which contains connective tissue protein to reduce the potential for post-implantation calcification and thrombogenicity, said method comprising the steps of:
The method of claim 64 wherein said terminal sterilization solution comprises an aqueous solution of 0.2-2.0% by weight glutaraldehyde buffered to a pH of approximately 7.4.
Dependencies are inferred from the claim text.