Radiation therapy using a radioactive implantable device and a radiosensitizer agent
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorTy T. Hu
Life of this patent
Estimating the term…
Abstract
A method and apparatus for inhibiting vascular restenosis using a radioactive implantable medical device and a radiosensitizer agent. In one embodiment, the method of the invention includes implanting a medical device at a blood vessel site that has undergone a procedure to open a stenosed region within a blood vessel. The medical device contains a radioisotope to emit a radioactivity to a tissue mass at the blood vessel site. The method further includes delivering a radiosensitizer agent to the tissue mass at the blood vessel site. The radiosensitizer agent increases a therapeutic response of the tissue mass to the radioactivity emitted by the radioisotope.
Claims57
A method comprising:
- implanting a medical device at a blood vessel site that has undergone a procedure to open a stenosed region within a blood vessel, the medical device comprising a radioisotope to emit a radioactivity to a tissue mass at the blood vessel site;
- and
- delivering a radiosensitizer agent to the tissue mass at the blood vessel site, the radiosensitizer agent increasing a therapeutic response of the tissue mass to the radioactivity emitted by the radioisotope by extending a range of a radiation dose beyond a length of the medical device.
A method for inhibiting restenosis, the method comprising:
- implanting a stent at a blood vessel site which has undergone a procedure to open a stenosed region within a blood vessel, the stent comprising a radioisotope to emit a radioactivity to a tissue mass at the blood vessel site;
- and
- delivering a radiosensitizer agent to the tissue mass at the blood vessel site, the radiosensitizer agent increasing a therapeutic response of the tissue mass to the radioactivity emitted by the radioisotope by extending a range of a radiation dose beyond a length of the medical device.
A radiation therapy system comprising:
- an implantable medical device comprising a radioisotope to emit a radioactivity to a tissue mass at a blood vessel site which has undergone a procedure to open a stenosed region within a blood vessel;
- and
- a radiosensitizer agent that increases a therapeutic response of the tissue mass to the radioactivity emitted by the radioisotope by extending a range of a radiation dose beyond a length of the medical device, wherein the radioisotope and the radiosensitizer agent are disposed at the blood vessel site during radiation therapy.
A method comprising:
- implanting a medical device at a blood vessel site, the medical device comprising a radioisotope to emit a radioactivity to a tissue mass at the blood vessel site;
- and
- delivering a radiosensitizer agent to the tissue mass at the blood vessel site, the radiosensitizer agent increasing a therapeutic response of the tissue mass to the radioactivity emitted by the radioisotope by extending a range of a radiation dose beyond a length of the medical device.
A radiation therapy system comprising:
- an implantable medical device comprising a radioisotope to emit a radioactivity to a tissue mass at a blood vessel site;
- and
- a radiosensitizer agent that increases a therapeutic response of the tissue mass to the radioactivity emitted by the radioisotope by extending a range of a radiation dose beyond a length of the medical device, wherein the radioisotope and the radiosensitizer agent are disposed at the blood vessel site during radiation therapy.
Dependencies are inferred from the claim text.