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US 6,545,170 B2Granted
2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
AssigneePharmacia Corporation
InventorsBarnett S. Pitzele, James A. Sikorski, Donald W. Hansen, Jr., Ronald Keith Webber, Mihaly V. Toth, Jeffrey A. Scholten, Jeffrey S. Snyder
Life of this patent
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Abstract
The present invention contains novel compounds useful as nitric oxide synthase inhibitors.
Claims30
A compound of Formula I
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is selected from the group consisting of H and methyl;
- and
- R2 is selected from the group consisting of H and methyl.
1 more element
A compound selected from the group consisting of:
- (2S,5Z)-2-amino-6-methyl-7-[(1-iminoethyl)amino]-5-heptenoic acid, dihydrochloride, monohydrate;
- (2S,5E)-2-amino-6-methyl-7-[(1-iminoethyl)amino]-5-heptenoic acid, dihydrochloride;
- (2S,5Z)-2-amino-5,6-dimethyl-7-[(1-iminoethyl)amino]-5-heptenoic acid, dihydrochloride;
- (2S,5Z)-2-amino-5-methyl-7-[(1-iminoethyl)amino]-5-heptenoic acid, dihydrochloride;
- (2S,5E)-2-amino-5,6-dimethyl7-[(1-iminoethyl)amino]-5-heptenoic acid, dihydrochioride;
- (2S,5Z)-2-amino-7-[(1-iminoethyl)amino]-5-heptenoic acid, dihydrochloride;
- (2S,5E)-2-amino-5-methyl-7-[(1-iminoethyl)amino]-5-heptenoic acid, dihydrochloride;
- (2S,5E)-2-amino-7-[(1-iminoethyl)amino]-5-heptenoic acid, dihydrochioride;
- (2R,5Z)-2-amino-7-[(1-iminoethyl)amino]-5-heptenoic acid, dihydrochloride;
- and
- (2R,5E)-2-amino-7-[(1-iminoethyl)amino]-5-heptenoic acid, dihydrochloride.
8 more elements
Dependencies are inferred from the claim text.