Back to results
US 6,545,030 B1Granted
1-heterocycle substituted diarylamines
AssigneeWarner-Lambert Company
InventorsStephen Douglas Barrett, Alexander James Bridges, Haile Tecle, Lu-Yan Zhang
Life of this patent
Estimating the term…
Abstract
1-Heterocycle substituted diarylamines, methods of making and using them, and compositions containing them.
Claims42
A compound of formula (I):
- W is one of the following formulae:
- X is NH;
- X2 is OH, SH, or NHRE;
- each of RE and RF is H or C1-4 alkyl;
- each of R1 and R2 is independently selected from H, F, NO2, Br and Cl;
- R1 can also be SO2NRGRH, or R1 and R2 together with the benzene ring to which they are attached constitute an indole, isoindole, benzofuran, benzothiophene, indazole, benzimidazole, or benzthioazole;
- R3 is H or F;
- each of RG, RH, and R4 is independently selected from H, Cl and CH3;
- and
- wherein each hydrocarbon radical above is optionally substituted with between 1 and 3 substituents independently selected from halo, hydroxyl, amino, (amino)sulfonyl, and NO2;
- and
- wherein each heterocyclic radical above is optionally substituted with between 1 and 3 substituents independently selected from halo, C3-4 alkyl, C3-6 cycloalkyl, C3-4 alkenyl, C3-4 alkynyl, phenyl, hydroxyl, amino, (amino)sulfonyl, and NO2, wherein each substituent alkyl, cycloalkyl, alkenyl, alkynyl or phenyl is in turn optionally substituted with between 1 and 2 substituents independently selected from halo, C1-2 alkyl, hydroxyl, amino, and NO2;
- or a pharmaceutically acceptable salt or C1-8 ester thereof.
10 more elements
A method of claim 41, wherein said infection is an infection of HIV.
Dependencies are inferred from the claim text.