Methods and devices for the removal of psoralens from blood products
AssigneeCerus Corporation
InventorDerek J. Hei
Life of this patent
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Abstract
Methods and devices for the removal of psoralens and psoralen photoproducts from blood products are described. The methods include contacting a psoralen- and irradiation-treated blood product with a resin capable of adsorbing psoralens and psoralen photoproducts. The removal process is particularly suitable for use with platelet concentrates and plasma because the process does not have a significant adverse effect on clotting factor function. The methods and devices can be incorporated with apheresis systems and other devices and procedures currently used to process blood products for transfusion.
Claims47
A blood-processing system that removes free psoralen and low molecular-weight psoralen photoproducts from a blood product to produce a blood product suitable for use in a human, said system comprising:
- a) a hemocompatible housing having walls that form a chamber;
- b) a hemocompatible resin comprising a hemocompatible macroreticular adsorbent resin having a network pore structure, wherein said hemocompatible resin resides within said chamber, wherein said hemocompatible resin possesses an affinity for said free psoralen and said low molecular-weight psoralen photoproducts, and wherein said hemocompatible resin does not require prewetting in a wetting solution to enable the resin to adsorb the free psoralen;
- and
- c) a hemocompatible filter that is configured to separate said hemocompatible resin from said blood product to provide treated blood product that is free of said resin.
A blood-processing system that removes free psoralen and low molecular-weight psoralen photoproducts from a blood product to produce a blood product suitable for use in a human, said system comprising:
- a) a hemocompatible housing having walls that form a chamber;
- b) a hemocompatible resin comprising a hemocompatible hypercrosslinked resin having a network pore structure, wherein said hemocompatible resin resides within said chamber and wherein said hemocompatible resin possesses an affinity for said free psoralen and said low molecular-weight psoralen photoproducts;
- and
- c) a hemocompatible filter that is configured to separate said hemocompatible resin from said blood product to provide treated blood product that is free of said resin.
Dependencies are inferred from the claim text.