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AssigneeKeraplast Technologies, Ltd.
InventorsArlene J. Siller-Jackson, Mark E. Van Dyke, Scott F. Timmons, Cheryl R. Blanchard, Robert A. Smith
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A hydratable, highly absorbent keratin solid fiber or powder capable of absorbing a large weight excess of water may be produced by partially oxidizing hair keratin disulfide bonds to sulfonic acid residues and reacting the sulfonic acid residues with a cation. The neutralized suspension can be filtered, washed, and dried, leaving keratin solid which can be shredded into fibers and further ground into powder. Addition of water to the solid produces a hydrogel. The powder or hydrogel may be useful as an absorbent material, as a therapeutic for skin, or as an excipient. The keratin materials can be incorporated into nonwoven films. The hydrogel can be used as a biocompatible viscoelastic filler for implant applications. Another use for the absorbent keratin and keratin hydrogel is as an excipient in pharmaceutical and cosmetic applications.
A preparation comprising a cross-linked insoluble keratin excipient associated with a pharmaceutical or cosmestic active agent, where said keratin excipient is chemically modified to contain sulfonate groups.
A method for the delivery of a pharmaceutical or cosmetic active agent comprising providing an active agent in a cross-linked insoluble keratin excipient, wherein said keratin excipient contains sulfonate groups.
A drug delivery preparation comprising a cross-linked insoluble keratin powder and a pharmaceutical agent wherein the keratin is chemically modified to contain sulfonate groups, and further wherein the keratin powder forms a hydrogel upon absorption of water.
A preparation comprising a cross-linked insoluble keratin powder and a cosmetic agent, wherein the keratin is chemically modified to contain sulfonate groups.
A preparation comprising a cross-linked insoluble keratin powder containing sulfonate groups, wherein the preparation further comprises acetaminophen, a tetracycline, a penicillin, a vitamin, an antacid a non-steroidal antiinflammatory agent, an anesthetic, a breath freshener, or a mineral.
Dependencies are inferred from the claim text.